Publications by authors named "Ceaser A Moses"
Long-term adverse effects on human health are caused by exogenous compounds that alter the functions of biological systems, especially neuroendocrine disruptors like diethyl phthalate (DEP) and bisphenol S (BPS). Although vanillic acid (VA) has pertinent neuropharmacological characteristics, its effect against DEP + BPS-induced neurotoxicity has not been explored. This study proposed that VA may offer protection against the neurotoxicity caused by DEP + BPS.
View Article and Find Full Text PDFMorin attenuates neurobehavioural deficits, hippocampal oxidative stress, inflammation, and apoptosis in rats co-exposed to bisphenol S and diethyl phthalate.
Brain Res
November 2022
Article Synopsis
- Endocrine-disrupting pollutants (EDPs) like Bisphenol S (BPS) and diethyl phthalates (DEP) are common environmental toxins that may cause neurotoxicity, which was examined in male Wistar rats.
- Exposure to a mixture of BPS and DEP resulted in anxiety-like behaviors, cognitive and motor impairments, and increased oxidative stress markers.
- Treatment with morin showed protective effects by improving neurobehavioral outcomes, reducing enzyme hyperactivity, and decreasing oxidative stress and inflammation in the rats.
Sub-acute exposure to Sudan IV-adulterated palm oil induces oxidative stress and represses the expression of Nrf2 and antioxidant genes in male albino rats.
J Environ Sci Health C Toxicol Carcinog
August 2021
This study investigated the effects of Sudan IV dye (S4D) on antioxidant biomarkers using palm oil adulterated with S4D. Thirty male albino rats were grouped into five (n = 6); Normal control, palm oil (PO), PO + S4D (100 mg/kg), PO + S4D (250 mg/kg), and S4D (250 mg/kg) for 21 days. Oxidative stress biomarkers were assessed in the serum, liver, and kidneys.
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