Anatomic distribution and analysis of influencing factors on deep vein thrombosis in patients with spinal fractures caused by high-energy injuries.

Purpose: To analyze the anatomic distribution and influencing factors on deep vein thrombosis (DVT) in patients with spinal fractures caused by high-energy injuries.

Methods: A retrospective analysis was performed on 302 patients of lower extremity DVT who were admitted to our hospital from January 2018 to December 2023. All patients underwent ultrasonography of DVT before and after surgery.

The Emerging Role of m6A and Programmed Cell Death in Cardiovascular Diseases.

N6-methyladenosine (m6A) is the most prevalent internal chemical modification in eukaryotic messenger RNA (mRNA), significantly impacting its lifecycle through dynamic and reversible processes involving methyltransferase, demethylase, and binding proteins. These processes regulate mRNA stability, splicing, nuclear export, translation, and degradation. Programmed cell death (PCD), a tightly controlled process encompassing apoptosis, pyroptosis, ferroptosis, autophagy, and necroptosis, plays a crucial role in maintaining cellular homeostasis, tissue development, and function.

Encoding of 2D Self-Centered Plans and World-Centered Positions in the Rat Frontal Orienting Field.

The neural mechanisms of motor planning have been extensively studied in rodents. Preparatory activity in the frontal cortex predicts upcoming choice, but limitations of typical tasks have made it challenging to determine whether the spatial information is in a self-centered direction reference frame or a world-centered position reference frame. Here, we trained male rats to make delayed visually guided orienting movements to six different directions, with four different target positions for each direction, which allowed us to disentangle direction versus position tuning in neural activity.

A polysaccharide from salviae miltiorrhizae radix inhibits weight gain of mice with high-fat diet via modulating intestinal bacteria.

Background: Obesity, a global chronic disease, has been recognized as a severe risk to health. In our study, a novel polysaccharide named ARS was isolated and purified from aerial part of salviae miltiorrhizae radix. Our aim is to investigate the weight-reducing effect of a polysaccharide from salviae miltiorrhizae radix on mice fed a high-fat diet.

Transcriptomic and methylomic analyses provide insights into the molecular mechanism and prediction of heterosis in rice.

Heterosis has been widely used in multiple crops. However, the molecular mechanism and prediction of heterosis remains elusive. We generated five F hybrids [four showing better-parent heterosis (BPH) and one showing mid-parent heterosis], and performed the transcriptomic and methylomic analyses to identify the candidate genes for BPH and explore the molecular mechanism of heterosis and the potential predictors for heterosis.

Transcriptome and de novo analysis of Rosa xanthina f. spontanea in response to cold stress.

Background: Rose is one of most popular ornamental plants worldwide and is of high economic value and great cultural importance. However, cold damage restricts its planting application in cold areas. To elucidate the metabolic response of rose under low temperature stress, we conducted transcriptome and de novo analysis of Rosa xanthina f.

Clinical outcome of chronic myeloid leukemia patients who switch from first-line therapy with a second generation tyrosine kinase inhibitor to an alternative TKI.

While second generation tyrosine kinase inhibitors (2GTKIs) are highly effective therapies for chronic myeloid leukemia (CML), a significant minority of patients who initiate a 2GTKI will require a switch to an alternative TKI. The long-term outcomes of those who require a change in therapy after front-line 2GTKI therapy are largely undescribed. Here we describe the clinical outcomes associated with switch to an alternative TKI after first-line therapy with a 2GTKI.

Efficacy of combined angiotensin II receptor blocker with tripterygium glycosides on diabetic nephropathy: A protocol for meta-analysis.

Background: Several studies have reported good results for angiotensin II receptor blockers (ARB) combined with tripterygium glycosides (TGs) in the treatment of diabetic nephropathy (DN). However, because a small number of cases were included in each study, the statistical power was limited. Therefore, we performed a protocol for meta-analysis to further evaluate the clinical efficacy and safety of combined ARB and TGs in treatment of DN.

Integrated multiomic analysis reveals comprehensive tumour heterogeneity and novel immunophenotypic classification in hepatocellular carcinomas.

Objective: Hepatocellular carcinoma (HCC) is heterogeneous, especially in multifocal tumours, which decreases the efficacy of clinical treatments. Understanding tumour heterogeneity is critical when developing novel treatment strategies. However, a comprehensive investigation of tumour heterogeneity in HCC is lacking, and the available evidence regarding tumour heterogeneity has not led to improvements in clinical practice.

Combination of Biomarkers in Predicting 28-Day Mortality for Septic Patients.

Objective: To estimate the value of combinative index (combination of routine biomarkers) for predicting 28-day mortality in patients with sepsis.

Study Design: An observational study.

Place And Duration Of Study: Department of Intensive Care Unit, the Second Hospital of Shandong University, Jinan, China, from August 2016 to December 2016.

Integration of lncRNA-miRNA-mRNA reveals novel insights into oviposition regulation in honey bees.

Background: The honey bee () is a highly diverse species commonly used for honey production and pollination services. The oviposition of the honey bee queen affects the development and overall performance of the colony. To investigate the ovary activation and oviposition processes on a molecular level, a genome-wide analysis of lncRNAs, miRNAs and mRNA expression in the ovaries of the queens was performed to screen for differentially expressed coding and noncoding RNAs.

A new nondestructive instrument for bulk residual stress measurement using tungsten k X-ray.

We describe an experimental instrument used for measuring nondestructively the residual stress using short wavelength X-ray, tungsten k. By introducing a photon energy screening technology, the monochromatic X-ray diffraction of tungsten k was realized using a CdTe detector. A high precision Huber goniometer is utilized in order to reduce the error in residual stress measurement.

Fabrication of Well-Ordered Three-Phase Boundary with Nanostructure Pore Array for Mixed Potential-Type Zirconia-Based NO2 Sensor.

A well-ordered porous three-phase boundary (TPB) was prepared with a polystyrene sphere as template and examined to improve the sensitivity of yttria-stabilized zirconia (YSZ)-based mixed-potential-type NO2 sensor due to the increase of the electrochemical reaction active sites. The shape of pore array on the YSZ substrate surface can be controlled through changing the concentration of the precursor solution (Zr(4+)/Y(3+) = 23 mol/L/4 mol/L) and treatment conditions. An ordered hemispherical array was obtained when CZr(4+) = 0.

The Value of BISAP Score for Predicting Mortality and Severity in Acute Pancreatitis: A Systematic Review and Meta-Analysis.

Purpose: The Bedside Index for Severity in Acute Pancreatitis (BISAP) score has been developed to identify patients at high risk for mortality or severe disease early during the course of acute pancreatitis. We aimed to undertake a meta-analysis to quantify the accuracy of BISAP score for predicting mortality and severe acute pancreatitis (SAP).

Materials And Methods: We searched the databases of Pubmed, Embase, and the Cochrane Library to identify studies using the BISAP score to predict mortality or SAP.

[Effect of bagging with different colors on the fruit coloration of 'yunhongli No.2' pear].

The present study was conducted to reveal the effect of bags with different colors on the fruit coloration of 'Yunhongli No. 2'. The differences in fruit skin color, chlorophyll, flavonoids, total phenol, anthocyanin contents and the activities of related enzymes involved in anthocyanin synthesis among different bagging treatments were evaluated.

[The clinical value of continuous perfusion percutaneous transluminal coronary angioplasty in treatment of coronary artery disease].

Fourty two patients with coronary artery disease were studied. Among them 22 were treated with continuous perfusion percutaneous transluminal coronary angioplasty (CPPTCA) and 20 with percutaneous transluminal coronary angioplasty (PTCA). It was found that patients treated with CPPTCA can stand longer time of dilatation during operation than those treated with PTCA (P < 0.