Identification of EDIL3 biomarkers as a biomarker and potential therapeutic target of canine mammary carcinomas based on integrated bioinformatics analysis.

As the fierce battle with cancer is now expanding to companion animals, effective treatment of canine mammary carcinomas (CMT), as the most frequently diagnosed tumor in intact dogs, is becoming a crucial issue. Although many studies have been carried out concerning the clinical application of mammary tumor biomarkers, no ideal biomarker has yet been identified in CMT. Therefore, in this work, we develop EDIL3 as a CMT biomarker having significantly higher expression levels in CMT samples compared to those in controls in GSE13754, GSE22516 and GSE25586 datasets, which suggest that EDIL3 is a gene related to tumorigenesis.

[Detection method of nonlinear magnetized harmonic signal of medical magnetic nanoparticles].

Medical magnetic nanoparticles are nano-medical materials with superparamagnetism, which can be collected in the tumor tissue through blood circulation, and magnetic particle imaging technology can be used to visualize the concentration of magnetic nanoparticles in the living body to achieve the purpose of tumor imaging. Based on the nonlinear magnetization characteristics of magnetic particles and the frequency characteristics of their magnetization, a differential detection method for the third harmonic of magnetic particle detection signals is proposed. It was modeled and analyzed, to study the nonlinear magnetization response characteristics of magnetic particles under alternating field, and the spectral characteristics of magnetic particle signals.

Modelling of Corrosion-Induced Concrete Cover Cracking Due to Chloride Attacking.

The premature failure of reinforced concrete (RC) structures is significantly affected by chloride-induced corrosion of reinforcing steel. Although researchers have achieved many outstanding results in the structural capacity of RC structures in the past few decades, the topic of service life has gradually attracted researchers' attention. In this work, based on the stress intensity, two models are developed to predict the threshold expansive pressure, corrosion rate and cover cracking time of the corrosion-induced cracking process for RC structures.

Supported Gold Nanoparticles as Catalysts in Peroxidative and Aerobic Oxidation of 1-Phenylethanol under Mild Conditions.

The efficiency of Au/TiO based catalysts in 1-phenylethanol oxidation was investigated. The role of support modifiers (LaO or CeO), influence of gold loading (0.5% or 4%) and redox pretreatment atmosphere, catalyst recyclability, effect of oxidant: -butyl hydroperoxide (TBHP) or O, as well as the optimization of experimental parameters of the reaction conditions in the oxidation of this alcohol were studied and compared with previous studies on 1-octanol oxidation.

[An efficacy and safety study of bifidobacterium tetragenous viable bacteria tablets in the treatment of constipation in patients with type 2 diabetes mellitus].

The incidence of gastrointestinal symptoms in diabetes is higher than that of non-diabetes. Thus, the aim of the present study was to observe the efficacy and safety of bifidobacterium tetragenous viable bacteria tablets in the treatment of constipation in patients with type 2 diabetes mellitus. This is a multicenter, randomized, double-blind, placebo-controlled, parallel group-comparison clinical research.

[The influence of combined use of rhPDGF-BB and rhTGF-β1 on protein expression of FAK in osteoclast during orthodontic tooth movement in rats].

Purpose: To explore the combined effects of recombinant human platelet-derived growth factor-BB(rhPDGF-BB)and recombinant human transforming growth factor-β1 (rhTGF-β1) on protein expression of FAK in osteolasts of the pressure side of orthodontic tooth in rats.

Methods: One hundred and sixty male Sprague-Dawley rats were randomly divided into 2 groups: experimental group(A) and control group(B). Each group was subdivided equally into 5 subgroups.

[The influence of salvia miltiorhiza on the expression of TGF-β1 in periodontal tissue during orthodontic tooth movement in rats].

Purpose: To investigate the effect of salvia miltiorhiza on the expression of TGF-β1 within periodontal tissues during orthodontic tooth movement in rat.

Methods: One hundred and ninety-two male Sprague-Dawley rats were randomly divided into 4 groups (group A, B, C and D). Group A and B were used as orthodontic tooth movement model based on afterburner time.

[Effect of tea polyphenols on proliferation of human periodontal ligament fibroblasts].

Objective: To determine the effect of tea polyphenol (TP) on the proliferation of human periodontal ligament fibroblasts (HPDLFs).

Methods: HPDLFs were primary cultured from tissue explants, and the cells of the 5th to 8th passages were used after immunohistochemical identification (with SABC method) of keratin and vimentin expressions. The cells were divided into 5 groups and treated with TP at 1, 0.

Study of the prevalence of diabetes mellitus in adults in the Shougang Corporation in Beijing.

The aim was to determine the burden of diabetes mellitus (DM) in an urban area of China to aid us in planning preventive measures for those at risk of DM. A survey was conducted among the 29,859 subjects aged between 30 and 64 belonging to 32 units of the Shougang Corporation (a heavy industry enterprise) within the Beijing area. WHO study protocols and diagnostic criteria were used to determine the prevalence of DM and impaired glucose tolerance (IGT).