Publications by authors named "Cayuela A"
Introduction: Lung cancer remains one of the leading causes of cancer death worldwide. This study examines lung cancer mortality trends in Andalusia, Spain, from 2003 to 2022, focusing on gender differences and the influence of age, period and cohort effects.
Material And Methods: This longitudinal ecological study analyzed lung cancer mortality data in Andalusia from 2003 to 2022, using age-period-cohort (A-P-C) and joinpoint regression models.
Objectives: This study examined the spatial patterns of systemic sclerosis mortality in Spain from 2003 to 2022, identifying provincial-level clusters and sex-specific differences to explore potential underlying factors.
Methods: Mortality and population data (2003-2022) were sourced from the National Institute of Statistics. Age-standardized mortality rates were calculated, and spatial patterns were analyzed using standardized mortality ratios and smoothed relative risks via the Besag, York, and Mollié model, with statistical inference performed using the Integrated Nested Laplace Approximation (INLA) technique.
Aim: To explore trends in multiple sclerosis incidence rates in Spain between 1990 and 2019.
Methods: We use data from the Global Burden of Disease Study 2019 to calculate age-standardised incidence rates of multiple sclerosis and identify significant changes over time using the Joinpoint regression model. We also use the Age-Period-Cohort model to understand the separate influences of age, historical period, and birth cohort on these trends.
Article Synopsis
- This study examined psoriasis prevalence in Spain from 2018 to 2022, finding a significant increase in cases, particularly among older age groups.
- The estimated prevalence reached 1.9% in 2022, with a total rise of 43.3%, indicating stronger increases in both men and women, with men showing slightly higher rates.
- Results suggest factors like better awareness and diagnostics may contribute to this trend, highlighting the need for more research to understand the causes and inform public health strategies.
Aim: This study aims to analyze trends in venous thromboembolism (VTE) mortality in the Spanish Autonomous Communities (ACs) from 1999 to 2022, with a focus on identifying regional disparities and informing targeted public health interventions.
Methods: Age-standardized mortality rates (ASMRs) were calculated using the European standard population as a reference. Joinpoint regression analysis was employed to identify significant changes in mortality trends, and geographical analysis was conducted using Bayesian inference to assess regional variations in mortality risk.
Article Synopsis
- The study analyzed melanoma mortality trends in Spain from 1999 to 2022, focusing on differences based on gender and age in various regions.
- Results revealed significant regional variations in mortality rates, with higher rates for men in Eastern Spain and higher rates for women in Asturias, while trends showed fluctuating changes in specific areas over time.
- The study emphasizes the need for ongoing monitoring and public health initiatives to address these disparities, particularly for older adults and men, to improve early detection and treatment access nationwide.
Divergent trends in gastric cancer incidence by sex and age in Spain (1990-2019).
Rev Esp Enferm Dig
September 2024
Article Synopsis
- - The study examines gastric cancer (GC) trends in Spain from 1990 to 2019, focusing on differences in incidence by sex and age.
- - While the total number of GC cases slightly increased, the age-standardized incidence rate (ASIR) declined annually by 1.8% for both men and women, with men consistently having a higher burden of the disease.
- - Notably, there was a significant decrease in ASIR among younger adults (<35 years), but a concerning rise was found in young men (25-34 years) between 2014-2019, indicating a need for further exploration of risk factors specific to this group.
Comprehensive analysis of multiple sclerosis hospitalization trends in Spain (1998-2022).
Mult Scler Relat Disord
November 2024
Article Synopsis
- - From 1998 to 2022, MS hospitalization rates in Spain decreased by an annual average of -2.1%, with women showing a slightly higher decline (-2.3%) than men (-1.7%).
- - Joinpoint analysis indicated non-parallel trends with three distinct periods of stabilization and decline, while age-standardized rates showed an overall drop, with rates peaking in younger age groups (25-29 for men and 30-34 for women).
- - The research highlights that the risk of MS hospitalization is influenced by age, birth cohort, and sex, showing a significant decline despite an aging population, especially among cohorts born in the early 20th century.
Objective: Genome wide association studies have identified an exon 6 deletion variant that associates with increased risk of pancreatic cancer. To acquire evidence on its causal role, we developed a new mouse strain carrying an equivalent variant in , the mouse orthologue of .
Design: We used CRISPR/Cas9 to introduce a 707bp deletion in encompassing exon 6 ( ).
Non-melanoma skin cancer (NMSC) is the most -common skin cancer in Spain, yet national data on its incidence trends are limited. To analyse the trends in NMSC incidence in Spain from 1990 to 2019, examining variations by sex, age, period, and birth cohort. Data on NMSC incidence was sourced from the Global Health Data Exchange.
View Article and Find Full Text PDFObjective: Despite global declines in asthma mortality, regional variations and sex disparities persist. This study investigates asthma mortality trends in Spanish Autonomous Communities (ACs) from 1980 to 2022, analyzing data by sex.
Methods: Data on asthma deaths and population were obtained from the National Institute of Statistics for the study period.
Aim: This study aimed to investigate the effects of age, period, and cohort on the incidence of psoriasis in Spain from 1990 through 2019 using the Global Burden of Disease (GBD) database and age-period-cohort (A-P-C) analysis.
Methods: We conducted an ecological trend study to analyze the incidence rates of psoriasis in Spain from 1990 through 2019. Joinpoint Regression Program, Version 5.
Article Synopsis
- This study analyzes lung cancer trends in Spain from 1990 to 2019, focusing on how age, period, and birth cohort affect incidence rates.
- It found that nearly 738,000 lung cancer cases were diagnosed, with an overall annual increase of 1.7%, but a rise in women’s incidence rates (2.5% annually) and a decline in men's rates (-0.6%).
- The results suggest a closing gender gap in lung cancer incidence due to decreasing smoking rates, highlighting the need for targeted prevention efforts for women and continued tobacco control measures.
Article Synopsis
- A study analyzed myelodysplastic neoplasm (MDS) mortality trends in Spain from 1999 to 2022, focusing on sex and regional differences.
- The research revealed varying MDS mortality rates among men and women across different regions, with significant trends identified: initial decline until 2008, an increase until 2017, and a notable decrease thereafter.
- Key findings included regional variations in mortality trends, with some areas like Andalusia experiencing increases, while others like Aragon saw declines; men consistently faced higher mortality risks than women, underscoring the need for localized healthcare strategies.
Article Synopsis
- Testicular cancer rates in Spain have doubled from 3.09 to 5.40 cases per 100,000 men between 1990 and 2019, indicating a 1.9% annual increase, while mortality rates have stabilized or decreased in younger groups.
- The study utilized the Global Burden of Disease database and the Age-Period-Cohort model to analyze trends and found a significant rise in incidence linked to successive generations born after 1935, contrasting with a decline in mortality among those born since the 1960s.
- Despite the decrease in mortality being a positive sign, the rising incidence trends highlight a need for further research to uncover the causes and develop effective prevention strategies for testicular cancer.
Posttranslational modifications (PTMs), particularly phosphorylation, play a pivotal role in expanding the complexity of the proteome and regulating diverse cellular processes. In this study, we present an efficient phosphorylation system designed to streamline the evaluation of potential substrates for plant kinases, although the technology is amenable to any. The methodology involves the use of IPTG-inducible vectors for co-expressing kinases and substrates, eliminating the need for radioactive isotopes and prior protein purification.
View Article and Find Full Text PDFObjective: This study aimed to assess the influence of age, period, and cohort (A-P-C) factors on kidney cancer (KC) incidence trends in Spain from 1990 to 2019.
Methods: Employing data from the Global Burden of Disease Study 2019, we employed joinpoint analysis to determine long-term patterns and A-P-C modelling to quantify net drift, local drift, longitudinal age curves, and rate ratios (RRs) of period and cohort effects.
Results: Over the period 1990-2019, an estimated 142,811 cases of KC were diagnosed in Spain.
Aim: This study aims to elucidate the factors driving melanoma incidence trends in Spain by analyzing the GBD-2019 dataset (1990-2019) and investigating the age-specific, birth cohort, and period effects on incidence rates.
Materials And Methods: This study analyzed melanoma incidence trends in Spain from 1990 to 2019 using an ecological design. Data were sourced from the Global Burden of Disease Study 2019 and Spain's National Statistics Institute.
To analyse changes in trends in mortality due to chronic obstructive pulmonary disease (COPD) in Spain by Autonomous Community (AC) and sex during the period 1980-2021. Data on population and COPD death records (International Classification of Diseases, 10 edition, codes J40â-"J44 and J47) were retrieved from the National Institute of Statistics for the study period. Age-standardised mortality rates by AC and sex were assessed using joinpoint regression models.
View Article and Find Full Text PDFBackground: Patterns of lung cancer (LC) mortality are important for planning health services and resource management.
Objectives: We aimed to provide updated information (1982-2021) and project (LC) mortality rates in Spain (2022-2046).
Method: We analysed data from the Spanish National Statistics Institute about mortality in LC (1982-2021), and we made predictions for the period 2022-2046.
Objective: The present study aims to assess the mortality trends in myelodysplastic syndromes (MDS) in Spain from 1980 to 2021.
Methods: Deaths and mid-year population data were collected from the National Institute of Statistics. We estimated age-standardised mortality rates (ASMRs) per 100,000 person-years for all ages and ages 35-64.
Objective: To analyse time trends in systemic lupus erythematosus (SLE) mortality and explore possible provincial clustering of SLE mortality in Spain (2001-2020).
Methods: We conducted an ecological study using deaths registered in SLE at the Spanish National Institute of Statistics between 2001 and 2020. Jointpoint regression models have been used to evaluate temporal trends.
Background: this study aimed to evaluate the effects of age, time period and cohort (A-P-C) on gastric cancer (GC) mortality in Spain from 1980 to 2021.
Methods: an ecological trend study was performed (with aggregated data obtained from the Spanish National Statistics Institute (INE). Joinpoint regression software was used to estimate rates by sex and age group (< 35, 35-64, > 64 years) and mortality trends.
Article Synopsis
- Macrophages are crucial immune cells that help maintain tissue health, defend against pathogens, and their function can be influenced by their metabolism.
- The study uses various advanced imaging and biochemical techniques to explore how growth hormone (GH) affects the metabolism of inflamed macrophages.
- Results show that GH reprograms these inflammatory macrophages by reducing their metabolism and enhancing mitochondrial function, indicating that targeting macrophage metabolism could be a new strategy for treating inflammatory diseases.