Disseminated leishmaniasis (DL) caused by is characterized by the presence of 10 to more than 1000 lesions spread on the body. While protection against is mediated by macrophages upon activation by IFN-γ produced by CD4T cells, the pathology of disseminated leishmaniasis (DL) could be mediated by macrophages, NK, and CD8T cells. Herein, we evaluate the participation of senescent CD8T cells in the pathogenesis of DL.
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