A mechanosensory defect in a amyloid-beta glutamatergic neuron model is reversed following exposure to species extracts.

Previous research has described promising neuroprotective and/or antioxidant properties for extracts derived from a few (sage) species. Here, six new species were isolated during flowering times from plants native to Turkey. Extracts were prepared and then examined for their potential to rescue both anterior and posterior mechanosensory behavioral defects in a transgenic Alzheimer's disease model that expresses human amyloid-beta (Aβ) peptide (1-42) exclusively in the glutamatergic neurons.

ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic .

Allele-specific distinctions in the human apolipoprotein E () locus represent the best-characterized genetic predictor of Alzheimer's disease (AD) risk. Expression of isoform ε2 is associated with reduced risk, while ε3 is neutral and ε4 carriers exhibit increased susceptibility. Using , we generated a novel suite of humanized transgenic nematodes to facilitate neuronal modeling of amyloid-beta peptide (Aβ) co-expression in the context of distinct human alleles.