Publications by authors named "Catriona Sinclair"
Article Synopsis
- Pityriasis rubra pilaris (PRP) is a rare skin disease that looks a lot like psoriasis and affects the skin on the palms and soles.
- Some recent treatments using special medicines called monoclonal antibodies have shown good results for people with PRP.
- One case of an adult diagnosed with an unusual type of PRP showed major improvement after receiving a specific treatment and emphasized the importance of genetic testing in figuring out tricky skin diseases.
Objective: We have developed an image analysis methodology for quantifying the anisotropy of neuronal projections on patterned substrates.
Approach: Our method is based on the fitting of smoothing splines to the digital traces produced using a non-maximum suppression technique. This enables precise estimates of the local tangents uniformly along the neurite length, and leads to unbiased orientation distributions suitable for objectively assessing the anisotropy induced by tailored surfaces.