Publications by authors named "Catriona R Stewart"
Article Synopsis
- * The OxHARP trial included 75 participants with mild-to-moderate brain changes and compared the effects of sildenafil, cilostazol, and a placebo over three weeks using various measures of brain blood flow and function.
- * Results showed that while sildenafil did not change cerebral pulsatility compared to placebo or cilostazol, it did lead to significant increases in blood flow, suggesting some positive effects on cerebrovascular function.
Cerebral small vessel disease (SVD) is a common cause of stroke, mild cognitive impairment, dementia and physical impairments. Differences in SVD incidence or severity between males and females are unknown. We assessed sex differences in SVD by assessing the male-to-female ratio (M:F) of recruited participants and incidence of SVD, risk factor presence, distribution, and severity of SVD features.
View Article and Find Full Text PDFCerebral small vessel disease (SVD) is a major contributor to stroke and dementia, characterized by white matter hyperintensities (WMH) on neuroimaging. WMH are associated with reduced cerebral blood flow (CBF) cross-sectionally, though longitudinal associations remain unclear. We updated a 2016 systematic review, identifying 30 new studies, 27 cross-sectional ( = 2,956) and 3 longitudinal ( = 440).
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