Publications by authors named "Catrina MacPhee"
Background: MMN and P3a are EEG-derived event related potentials that are thought to be prospective biomarkers for schizophrenia and, potentially, early-phase psychosis (EPP).
Methods: EPP (n = 12) and healthy control (HC; n = 35) participants listened to a multi-feature optimal paradigm with five deviant types (gap, duration, location, intensity, and frequency).
Results: There was a significant amplitude difference between the EPP and HC group with duration MMN (p = .
Article Synopsis
- The study analyzed mismatched negativity (MMN) and P3a waveforms in individuals with early-phase psychosis (EPP) and healthy controls to explore their potential as schizophrenia biomarkers.
- Both waveforms did not show significant differences in amplitude between groups; however, negative symptoms like asociality and blunted affect correlated with reduced MMN and P3a.
- Findings indicate that instead of serving as biomarkers, MMN and P3a may be better indicators of illness progression and symptom severity in the early phases of psychosis.
Article Synopsis
- The study focuses on two brain waveforms, MMN and P3a, which are indicators of how we detect changes in sounds.
- MMN reflects difficulties in auditory change detection, while P3a relates to the conscious evaluation of those sounds.
- The researchers found no significant sex differences in these waveforms among healthy individuals, contributing valuable information to the existing research on how biological sex might influence auditory processing.