Publications by authors named "Cathy Z L Chen"
Background: Epistaxis is common with antithrombotic therapy and is often troublesome to patients, yet its frequency, severity, and outcomes are poorly characterized.
Methods And Results: Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48 (ENGAGE AF-TIMI 48) randomized 21 105 patients with atrial fibrillation and CHADS2 risk score ≥2 to higher-dose edoxaban regimen (60 mg daily, dose-reduced to 30 mg), lower-dose edoxaban regimen (30 mg, dose reduced to 15 mg, daily), or warfarin. Bleeds were adjudicated using International Society on Thrombosis and Haemostasis criteria.
Article Synopsis
- * The ENGAGE AF-TIMI 48 trial involved a global double-blind study with 2966 older participants, comparing two dosing regimens of edoxaban and warfarin, focusing on those without dose-reduction criteria.
- * Key findings included a higher incidence of gastrointestinal hemorrhage associated with the 60 mg edoxaban dose, indicating the need for careful dose management in older patients on anticoagulants.