Publications by authors named "Cathy Sarta"
Occult Nodal Disease and Occult Extranodal Extension in Patients With Oropharyngeal Squamous Cell Carcinoma Undergoing Primary Transoral Robotic Surgery With Neck Dissection.
JAMA Otolaryngol Head Neck Surg
August 2019
Article Synopsis
- - The study investigates the rate of nodal upstaging and hidden extranodal extension in patients with oropharyngeal squamous cell carcinoma (OPSCC) who underwent transoral robotic surgery and neck dissection, amid changing causes of the disease, particularly with human papillomavirus becoming more prevalent.
- - Conducted across three institutions, the research included 92 patients, primarily male with a mean age of about 59, and aimed to compare preoperative imaging results against postoperative pathology to assess the presence of undetected nodal disease.
- - Findings revealed that 28% of patients with no visible nodal disease on imaging actually had occult pathology, indicating a significant rate of undetected disease that could impact postoperative treatment decisions.
Background: Knowledge of the rate of occult contralateral nodal disease for oropharynx cancers (OPSCC) in the era of Human Papillomavirus-dominated disease would inform practitioners as to who may be a candidate for unilateral neck management. The objective of this study was to determine the rate of pathologic contralateral positive nodes in patients in OPSCC patients with pT1 and pT2 disease treated with TORS and bilateral neck dissections (BND).
Methods: Retrospective review of medical records was performed at Princess Margaret Cancer Center, Toronto; Icahn School of Medicine at Mount Sinai, New York City; and Montefiore Medical Center, New York City.
Mucoepidermoid carcinoma (MEC) is a relatively common salivary tumor with varying potential for aggressive behavior. Mucoepidermoid carcinoma grading has evolved from descriptive two-tiered schemata to more objective three-tiered systems. In 2001, we published a grading system Brandwein et al.
View Article and Find Full Text PDFIdentification of epigenetically affected genes has become an important tool for understanding both normal and aberrant gene expression in cancer. Here we report a whole-genome analysis of DNA methylation profiles in fresh-frozen oropharyngeal squamous cell carcinoma (OPSCC) tissues and normal mucosa samples using microarray technology with patient genomic DNA. We initially compared whole-genome patterns of DNA methylation among 24 OPSCC primary tumors and 24 matched normal mucosal samples.
View Article and Find Full Text PDFBackground: Half of the patients with head and neck squamous cell carcinoma (HNSCC) can be expected to fail therapy, indicating that more aggressive treatment is warranted for this group. We have developed a novel risk model that can become a basis for developing new treatment paradigms. Here we report on the performance of our model in a new multicenter cohort.
View Article and Find Full Text PDF