Pulsed Reduced Dose Rate Radiotherapy in Conjunction With Bevacizumab or Bevacizumab Alone in Recurrent High-grade Glioma: Survival Outcomes.

Purpose: Dismal prognosis and limited treatment options for recurrent high-grade glioma have provoked interest in various forms of reirradiation. Pulsed reduced dose rate radiation therapy (pRDR) is a promising technique that exploits low-dose hyper-radiosensitivity of proliferating tumor cells while sparing adjacent nonproliferating normal brain tissue. Large radiation treatment volumes can thus be used to target both contrast-enhancing and FLAIR abnormalities thought to harbor recurrent gross and microscopic disease, respectively.

Quantifying metal-induced susceptibility artifacts of the instrumented spine at 1.5T using fast-spin echo and 3D-multispectral MRI.

Purpose: To evaluate magnetic resonance imaging (MRI) artifacts near metallic spinal instrumentation using both conventional metal artifact reduction sequences (MARS) and 3D multispectral imaging sequences (3D-MSI).

Materials And Methods: Both MARS and 3D-MSI images were acquired in 10 subjects with titanium spinal hardware on a 1.5T GE 450W scanner.

External calibration of the spectral coverage for three-dimensional multispectral MRI.

Purpose: By combining images created at distinct frequency offsets from the Larmor frequency, three-dimensional (3D) multispectral imaging (3D-MSI) sequences help overcome the large spatial frequency dispersion caused by metal implants. This frequency dispersion, however, varies with the implant size, orientation, and composition. Using a MAVRIC 3D-MSI acquisition, we sought to prospectively calibrate the spectral coverage needed for 3D-MSI scans.