Protective effect of methylprednisolone on warm ischemia-reperfusion injury in a cholestatic rat liver.

Background: Cholestasis has been identified as a risk factor for oxidative stress, and it potentially enhances after ischemic-reperfusion injury. The aim of this study was to evaluate the role of methylprednisolone on warm ischemia-reperfusion injury in the presence of cholestasis.

Methods: A reversible cholestatic rat model was created.