Stability of cough reflex sensitivity during viral upper respiratory tract infection (common cold).

Cough is among the symptoms most commonly associated with an acute, viral upper respiratory tract infection (URI), such as the common cold. Two previous studies incorporating capsaicin cough challenge methodology have demonstrated that cough reflex sensitivity is transiently enhanced during URI. These studies used single measurements of cough reflex sensitivity during the URI period.

Gene expression profiles during in vivo human rhinovirus infection: insights into the host response.

Rationale: Human rhinovirus infections cause colds and trigger exacerbations of lower airway diseases.

Objectives: To define changes in gene expression profiles during in vivo rhinovirus infections.

Methods: Nasal epithelial scrapings were obtained before and during experimental rhinovirus infection, and gene expression was evaluated by microarray.