Publications by authors named "Cathy Aj Bosch"
Article Synopsis
- - During skeletal development, beta-catenin levels, influenced by the Apc gene, are crucial for determining whether precursor cells become bone-forming osteoblasts or cartilage-forming chondrocytes.
- - Researchers created mice with a specific deletion of the Apc gene in cells that express Col2a1, leading to increased beta-catenin levels and severe skeletal defects, including perinatal death and malformed bones.
- - The study found that Apc is necessary for proper differentiation of skeletal stem cells; without it, most cells fail to mature into chondrocytes or osteoblasts, although some rib precursor cells managed to become active osteoblasts despite Apc loss.
