Publications by authors named "Cathrin Scherner"
Tyrosinase inhibitors are of great clinical interest as agents for the treatment of hyperpigmentary disorders; however, most compounds described in the literature lack clinical efficiency due to insufficient inhibitory activity against human tyrosinase (hTyr). Recently, we reported that thiazolyl resorcinols (4-resorcinylthiazol-2-amines and -amides) are both selective and efficacious inhibitors of hTyr in vitro and in vivo. Here, we measured dose-activity profiles of a large number of thiazolyl resorcinols and analogous compounds to better understand the molecular basis of their interaction with hTyr.
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- Tyrosinase is crucial for melanin production and a key target for treating hyperpigmentation, but many existing inhibitors are ineffective when using human tyrosinase in studies.
- A high-throughput screening of 50,000 compounds identified Thiamidol as the most effective human tyrosinase inhibitor, showing significant melanin reduction in melanocyte cultures compared to traditional inhibitors like hydroquinone and arbutin.
- Clinical trials indicate that Thiamidol can visibly reduce age spots in as little as 4 weeks, with ongoing studies needed to further establish its potential for treating hyperpigmentation.