Publications by authors named "Cathleen Cooper"
Article Synopsis
- - Mitochondrial complex V is crucial for ATP production, with most of its subunits encoded by nuclear genes; a specific splice variant (c.87+3A>G) in the ATP5PO gene was found in three individuals suspected of having a mitochondrial disorder.
- - The affected individuals exhibited severe symptoms typical of Leigh syndrome, including developmental issues and cardiomyopathy, and biochemical studies revealed a significant reduction in ATP5PO protein levels and impaired complex V function.
- - Experimental results indicated that the ATP5PO variant leads to a non-functional protein due to the skipping of an essential exon, confirming its pathogenic role and linking it to defects in mitochondrial energy production.
Reliability of 3 Strategies of Orbital Tumor Volume Measurement Using Phantom Modeling.
Ophthalmic Plast Reconstr Surg
May 2021
Purpose: The reliability of 3 volume measurement strategies was investigated using MRI and a simple method for creating phantom orbit tumors.
Methods: Water-based starch was molded into orbital "tumors" of 3 shapes (sphere, ovoid, diffuse); water displacement was used to calculate volume. "Tumors" were placed into 3D-printed orbit phantoms, MRIs were obtained and volume analysis was performed.
Virtual septal myectomy for preoperative planning in hypertrophic cardiomyopathy.
J Thorac Cardiovasc Surg
August 2019
Objective: Although septal myectomy (SM) is the preferred treatment for medication-refractory obstructive hypertrophic cardiomyopathy, the procedure remains subjective. We have developed a virtual myectomy (VM) technique using 3-dimensional reconstruction of gated cardiac computed tomography (CT) to assist intraoperative objective assessment of the adequacy of the resection.
Methods: We retrospectively reviewed patients 15 patients who underwent a SM guided by preoperative VM at our program between March 2016 and July 2017.
Advanced imaging modalities provide essential anatomic and spatial information in patients with complex heart disease. Two-dimensional imaging can be limited in the extent to which true 3-dimensional (3D) relationships are represented. The application of 3D printing technology has increased the creation of physical models that overcomes the limitations of a 2D screen.
View Article and Find Full Text PDFObjective: The objective of this study is to assess the sigmoid distensibility during CT colonography (CTC) in patients with diverticular disease.
Methods: Consecutive patients without a history of pelvic radiation or neoplasms underwent 150 CTC. Three radiologists in consensus evaluated axial images for colonic distention, luminal diameters (mm), diverticula, and muscular thickening.
Purpose: To assess the effect of commonly used computed tomographic (CT) section thicknesses on metastatic tumor measurements calculated with unidimensional, bidimensional, area, and volumetric methods.
Materials And Methods: Analysis and data collection were approved by the Institutional Review Board, with waived informed patient consent. Forty-two pulmonary metastases in 10 patients (three men and seven women; age range, 43-83 years; mean age, 65.
Rationale And Objectives: The authors performed this study to assess the usefulness of the various features of their radiology department intranet and to quantify its effect in facilitating intradepartmental information flow.
Materials And Methods: The number, length, and nature of visits to each directory on the intranet were recorded by a commercially available intranet analysis software package.
Results: During the last 6 months of 2001, 89,411 page views (mean, 485 per day) occurred during 26,344 visits to the radiology department intranet.
Objective: In patients who have a history of abdominopelvic radiation, surgery, or both, conventional colonoscopy may fail to examine the entire colon. The purpose of this study is to assess whether high-quality virtual colonoscopy can be achieved in this patient population.
Materials And Methods: After colonic cleansing, 61 patients (16 men and 45 women; mean age, 64 years; age range, 27-81 years) underwent 63 virtual colonoscopy examinations after using either single- or multidetector CT (slice thickness, 3.