Global feather orientations changed by electric current.

During chicken skin development, each feather bud exhibits its own polarity, but a population of buds organizes with a collective global orientation. We used embryonic dorsal skin, with buds aligned parallel to the rostral-caudal body axis, to explore whether exogenous electric fields affect feather polarity. Interestingly, brief exogenous current exposure prior to visible bud formation later altered bud orientations.

Feather on the Cap of Medicine.

Through cyclic regeneration, feather stem cells are molded into different shapes under different physiological states. With its distinct morphology, context-dependent growth, and experimental manipulability, the feather provides a rich model to study growth control, regeneration, and morphogenesis in vivo. Recent examples include novel insights revealed by transient perturbation with chemotherapeutic reagents and irradiation during feather growth.

Dsk1p kinase phosphorylates SR proteins and regulates their cellular localization in fission yeast.

Evolutionarily conserved SR proteins (serine/arginine-rich proteins) are important factors for alternative splicing and their activity is modulated by SRPKs (SR protein-specific kinases). We previously identified Dsk1p (dis1-suppressing protein kinase) as the orthologue of human SRPK1 in fission yeast. In addition to its similarity of gene structure to higher eukaryotes, fission yeast Schizosaccharomyces pombe is a unicellular eukaryotic organism in which alternative splicing takes place.