Publications by authors named "Catherine Truman"
The human immunodeficiency virus type 1 (HIV-1) proteome is expressed from alternatively spliced and unspliced genomic RNAs. However, HIV-1 RNAs that are not fully spliced are perceived by the host machinery as defective and are retained in the nucleus. During late infection, HIV-1 bypasses this regulatory mechanism by expression of the Rev protein from a fully spliced mRNA.
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- Yellow oleander is a toxic plant containing cardiac glycosides that can adversely affect the heart and nervous system; this study reviews cases of oleander poisoning and patient outcomes.
- Data from 30 adult patients showed common symptoms like vomiting, with metabolic issues such as hyperchloremia and metabolic acidosis frequently observed; half of the patients had ECG abnormalities.
- The use of temporary pacemakers in patients was linked to a longer hospital stay and the study highlights the need for further research on pacing's impact on survival in these cases.
Introduction: According to the World Health Organization (WHO) definition, an Adverse Drug Reaction (ADR) is a response to a drug that is noxious and unintended and occurs at doses normally used in humans for the prophylaxis, diagnosis, and treatment of disease. The risk factors of ADR are multi-factorial and include poly-pharmacy, age, gender, race, genetics and inter-current disease.
Patients And Methods: This was a hospital based, prospective, observational cohort study undertaken in a tertiary care hospital in south India to assess the different patterns of adverse drug reaction in medical wards over 6 months.