Publications by authors named "Catherine Sabourin-Poirier"
The growing interest in the use of lentiviral vectors (LVs) for various applications has created a strong demand for large quantities of vectors. To meet the increased demand, we developed a high cell density culture process for production of LV using stable producer clones generated from HEK293 cells, and improved volumetric LV productivity by up to fivefold, reaching a high titer of 8.2 × 10 TU/mL.
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- BLyS/BAFF is important for the development of B-cells and their decision-making in forming a group known as marginal zone B-cells, and too much of it can lead to issues in the immune system.
- In a study of highly-exposed seronegative commercial sex workers (HESNs), researchers found that these individuals had lower levels of soluble BLyS/BAFF and fewer B-cells expressing this factor compared to both HIV-infected and uninfected controls.
- Despite similar levels of total IgA across all groups, HESNs had lower levels of specific IgG subclasses, but some HESNs did produce IgG1 that reacted with HIV, suggesting that their lower BL
We have previously shown that excess B lymphocyte Stimulator (BLyS)/BAFF in plasma and on surface of blood dendritic cells (DC) of HIV-infected progressors coincides with B-cell dysregulations and increased frequencies of "precursor" innate marginal zone (MZ)-like B-cells. In contrast, both blood BLyS levels and frequencies of this population remained unaltered in HIV elite-controllers. Based on these observations, we hypothesized that control of BLyS and innate B-cell status could be associated with natural immunity against HIV infection.
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