Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabelling.

Gallium-68 (Ga) is a positron-emitting isotope used for clinical PET imaging of peptide receptor expression. Ga radiopharmaceuticals used in molecular PET imaging consist of disease-targeting biomolecules tethered to chelators that complex Ga. Ideally, the chelator will rapidly, quantitatively and stably coordinate Ga at room temperature, near neutral pH and low chelator concentration, allowing for simple routine radiopharmaceutical formulation.

Advances in cobalt complexes as anticancer agents.

The evolution of resistance to traditional platinum-based anticancer drugs has compelled researchers to investigate the cytostatic properties of alternative transition metal-based compounds. The anticancer potential of cobalt complexes has been extensively studied over the last three decades, and much time has been devoted to understanding their mechanisms of action. This perspective catalogues the development of antiproliferative cobalt complexes, and provides an in depth analysis of their mode of action.