Epidermodysplasia verruciformis in lipoid proteinosis: case report and discussion of pathophysiology.

Lipoid proteinosis (LP) is a rare autosomal recessive genodermatosis caused by mutations in extracellular matrix protein 1 (ECM1) that involves deposition of basement membrane-like material in the skin and other organs. Epidermodysplasia verruciformis (EV) is also a rare autosomal recessive genodermatosis involving susceptibility to human papillomavirus (HPV) infections and squamous cell carcinoma, caused in most cases by homozygous mutations in EVER1 or EVER2. We describe a case of EV in a patient with LP and discuss the pathophysiology.

Novel case of generalized multinucleate cell angiohistiocytoma.

Background: multinucleate cell angiohistiocytoma is a rare benign fibrohistiocytic and vascular proliferation, typically characterized by the development of solitary papules, in an acral distribution in otherwise healthy late middle-aged to elderly women.

Objective: our objectives are to present a novel case of generalized multinucleate cell angiohistiocytoma and to review the current literature regarding the clinical and histologic findings in this condition, as well as its potential causes and treatments.

Observations: we describe a 35-year-old man who presented with generalized asymptomatic firm violaceous papules.

An unusual case of turban tumor syndrome treated with total scalp excision and advancement flap and skin graft reconstruction.

We report an unusual case of aggressive turban tumor syndrome in a 38-year-old woman with nodules covering her scalp and involving her face, neck, chest, and back. To address concerns regarding hygiene of the scalp and cosmetic disfigurement, she underwent total scalp excision with advancement flap and skin graft reconstruction. Histologic examination of the scalp tumors revealed a predominance of spiradenomas, along with cylindromas and trichoepitheliomas, and tumors containing elements of all 3 of these adnexal neoplasms.

Development of an in vitro model for study of the efficacy of ischemic preconditioning in human skeletal muscle against ischemia-reperfusion injury.

Ischemia-reperfusion (I/R) injury causes skeletal muscle infarction and ischemic preconditioning (IPC) augments ischemic tolerance in animal models. To date, this has not been demonstrated in human skeletal muscle. This study aimed to develop an in vitro model to investigate the efficacy of simulated IPC in human skeletal muscle.

Prospective study of outcomes after reduction mammaplasty: long-term follow-up.

Background: The purpose of this prospective study was to determine whether the beneficial effects of reduction mammaplasty are maintained over the long term in a Canadian population and to determine whether reduction mammaplasty facilitates weight loss in the overweight patient.

Methods: The Short Form-36, Rosenberg Self-Esteem Scale, and Symptom Inventory Questionnaire were used to assess 57 patients preoperatively and postoperatively at 6 months and 21.5 months.

Endometriosis in the canal of Nuck: Atypical manifestations in an unusual location.

The canal of Nuck is an embryological remnant of the processus vaginalis and has been described as a site for endometriosis seeding. Endometriosis localized to the canal of Nuck is exceedingly rare with three cases reported. The case of a 31-year-old woman with an endometrioma in the canal of Nuck, made diagnostically challenging by atypical imaging and clinical findings, is described.