Publications by authors named "Catherine N Knowlson"
Article Synopsis
- - The study compares the effectiveness of two treatments for Dupuytren's contracture: collagenase injection and limited fasciectomy, using a randomized controlled trial with 672 participants
- - The main measurement tool used was the Patient Evaluation Measure-Hand Health Profile (PEM), where scores range from 0 to 100, with higher scores indicating worse hand health; results showed a mean score of 17.8 for the collagenase group and 11.9 for the limited-fasciectomy group at 1 year
- - The findings concluded that collagenase injection was not as effective as limited fasciectomy after one year, with fewer complications reported in the collagenase group (1.8%) compared to the limited-fasc
Early large treatment effects can arise in small studies, which lessen as more data accumulate. This study aimed to retrospectively examine whether early treatment effects occurred for two multicentre orthopaedic randomized controlled trials (RCTs) and explore biases related to this. Included RCTs were ProFHER (PROximal Fracture of the Humerus: Evaluation by Randomisation), a two-arm study of surgery versus non-surgical treatment for proximal humerus fractures, and UK FROST (United Kingdom Frozen Shoulder Trial), a three-arm study of two surgical and one non-surgical treatment for frozen shoulder.
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