Intact or broken-apart RNA: an alternative concept for ALK fusion screening in non-small cell lung cancer (NSCLC).

Anaplastic lymphoma kinase (ALK) break-apart fluorescent in situ hybridization (FISH) is currently used in diagnostics for the selection of non-small cell lung cancer (NSCLC) patients to receive crizotinib. We evaluated ALK status in NSCLC with a novel ALK mRNA test based on the break-apart FISH concept, which we called break-apart transcript (BAT) test. ALK5' and ALK3' transcript patterns were established with qPCR for ALK-expressing controls including fusion-negative neuroblastomas, as well as fusion-positive anaplastic large cell lymphomas and NSCLC.

Treatment of central giant-cell granulomas of the jaws in children: conservative or radical surgical approach?

Introduction: Although central giant-cell granulomas of the jaws (CGCG) tend to appear more often in children and young adults, most studies include patients of all ages.

Aim: Aim of this study was to present and discuss the characteristics, the selected treatment pattern and the outcome of central giant-cell granulomas of the jaws exclusively in children up to 13 years old, during a 10 years period.

Material And Method: Twelve young patients, 5-13 years old were included in the study.

Sinonasal myxoma in an infant.

Myxomas of the maxillofacial region are neoplastic entities of mesenchymal origin most often associated with odontogenic origin; sinonasal myxoma is rare, located in the nasolabial region and originating from the sinonasal tract. The aim of the current study was to report a well-documented case of sinonasal myxoma in a 12-month-old boy, initially presenting with obliteration of his left nasolacrimal duct. A soft-tissue mass of the nasobuccal groove, firmly attached to the underlying bone, was revealed.