Acute promyelocytic leukaemia is characterized by stable incidence and improved survival that is restricted to patients managed in leukaemia referral centres: a pan-Canadian epidemiological study.

Timely diagnosis and care are major determinants of the outcome in acute promyelocytic leukaemia (APL), a malignancy whose incidence may be increasing. The Canadian Cancer Registry (CCR) and health system represent valuable settings to study APL epidemiology. We analysed the CCR, which contains data on all Canadians with APL.

Action Thresholds for Summer Fungicide Sprays and Sequential Classification of Apple Scab Incidence.

The objectives of this study were to establish scab incidence thresholds at which summer fungicide sprays should be initiated and to develop sequential sampling for classification plans to facilitate decision making. The relationship between proportion of scabbed leaves per shoot and percent scabbed fruits at harvest was established based on data collected in both experimental and commercial orchards. Action threshold at which fungicide spray program should be initiated in order to maintain fruit scab at harvest below 2% was established at 0.

Airway smooth muscle cells express functional neurokinin-1 receptors and the nerve-derived preprotachykinin-a gene: regulation by passive sensitization.

Preprotachykinin-A (PPT-A) gene-derived neuropeptides, namely substance P (SP) and neurokinin (NK)A, and their receptors participate in allergen-induced airway responses. Whether airway smooth muscle cells (ASMC) may react directly to SP through expression of the NK-1 receptor or express the gene for the synthesis of SP, the PPT-A gene, is unknown. We demonstrated using reverse transcription-polymerase chain reaction that tracheal SMC (TSMC) from atopic Brown Norway rats contained mRNA transcripts for the full-length isoform of the NK-1 receptor.