Publications by authors named "Catherine M Marando"
Evidence for Complementary and Alternative Therapies to Treat Glaucoma.
Semin Ophthalmol
January 2023
Complementary and alternative medicine is used by approximately 5% of patients with glaucoma, and examples include marijuana, extract, bilberry fruit extract, and acupuncture. Systemic marijuana is not beneficial for glaucoma due to the short duration of action, the lack of evidence that it alters disease progression, and its negative side effect profile. Drops that affect the cannabinoid pathway are still being studied.
View Article and Find Full Text PDFArticle Synopsis
- Two pediatric cases of reticular corneal epithelial edema were reported after using netarsudil ophthalmic solution 0.02%.
- In the first case, a six-year-old developed the edema after glaucoma surgery and treatment with netarsudil, while the second case involved a three-month-old with edema appearing five weeks post-treatment.
- Both cases resolved after stopping the use of netarsudil, highlighting the potential side effects of this medication in young patients.
Intraoperative Suggestions for Documentation of Complex Ocular Surface and Eyelid Biopsies.
Ophthalmic Plast Reconstr Surg
March 2021
Purpose: The purpose of the study was to evaluate the tolerability and functionality of a wireless ocular telemetry sensor in African American patients with glaucoma.
Materials And Methods: In this prospective, observational cohort study, 20 African American patients with primary open angle glaucoma (POAG) were evaluated at the University of Colorado Eye Center. Before lens placement, patients recorded ocular comfort and underwent a baseline eye exam.
Article Synopsis
- The study aimed to investigate the structure of collagen and elastin at the junction of the human cornea and trabecular meshwork (TM).
- Imaging was done using a specialized microscope to capture and analyze the arrangement of these proteins in corneal tissue.
- Findings revealed that collagen-rich tendons from the ciliary body connect to the cornea and are surrounded by an elastin network, suggesting a relationship between this architecture and potential complications during corneal surgical procedures.
Article Synopsis
- The study focuses on the structure and distribution of collagen and elastin in specific eye tissues: limbal conjunctiva, Tenon's capsule, and sclera.
- Researchers used advanced imaging techniques without needing to fix the samples, effectively capturing detailed images of these fibers.
- Findings indicate that collagen density increases from the conjunctiva to the sclera, with collagen bundles varying in size and organization, while elastin fibers are thinner and less densely packed, showing different orientations in relation to collagen.
Role of nitric oxide in murine conventional outflow physiology.
Am J Physiol Cell Physiol
August 2015
Elevated intraocular pressure (IOP) is the main risk factor for glaucoma. Exogenous nitric oxide (NO) decreases IOP by increasing outflow facility, but whether endogenous NO production contributes to the physiological regulation of outflow facility is unclear. Outflow facility was measured by pressure-controlled perfusion in ex vivo eyes from C57BL/6 wild-type (WT) or transgenic mice expressing human endothelial NO synthase (eNOS) fused to green fluorescent protein (GFP) superimposed on the endogenously expressed murine eNOS (eNOS-GFPtg).
View Article and Find Full Text PDFSodium 4-phenylbutyrate (4PBA) corrects trafficking of ΔF508-CFTR in Cystic Fibrosis (CF) epithelia, which is hypothesized to, at least in part, result from increased expression of Hsp70 (stress-induced 70 kDa heat shock protein). To identify other 4PBA-regulated proteins that may promote correction of ΔF508 trafficking, we performed differential display RT-PCR on mRNA from IB3-1 CF bronchiolar epithelial cells treated for 0-24 h with 1 mM 4PBA. In this screen, a STAT-3 (signal transducer and activator of transcription-3)-interacting protein, StIP-1 that regulates STAT-3 activation had transiently increased expression.
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