Publications by authors named "Catherine M Della Santina"
Expansion microscopy (ExM) enables nanoscale imaging using a standard confocal microscope through the physical, isotropic expansion of fixed immunolabeled specimens. ExM is widely employed to image proteins, nucleic acids, and lipid membranes in single cells; however, current methods limit the number of samples that can be processed simultaneously. We developed High-throughput Expansion Microscopy (HiExM), a robust platform that enables expansion microscopy of cells cultured in a standard 96-well plate.
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- The study develops a network propagation framework aimed at predicting human proteins that interact with SARS-CoV-2, emphasizing the importance of provenance tracing to understand how input data influences prediction scores.
- The framework includes a method to link each prediction to experimentally validated sources, revealing that top predictions are largely influenced by neighboring proteins in a human interaction network.
- The findings offer new insights into viral infections and suggest potential drug repositioning opportunities, while also highlighting the framework's applicability to other emerging viruses.