Publications by authors named "Catherine Lu Dugan"
Background: Magnetic resonance image only (MRI-only) simulation for head and neck (H&N) radiotherapy (RT) could allow for single-image modality planning with excellent soft tissue contrast. In the MRI-only simulation workflow, synthetic computed tomography (sCT) is generated from MRI to provide electron density information for dose calculation. Bone/air regions produce little MRI signal which could lead to electron density misclassification in sCT.
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- Researchers studied how axillary surgery practices have changed over time following neoadjuvant chemotherapy (NAC) in breast cancer patients enrolled in the I-SPY2 trial from 2011 to 2021.
- The findings showed a significant decrease in axillary lymph node dissection (ALND) procedures, particularly in patients who were clinically node-positive (cN+) at diagnosis, with a corresponding increase in the use of sentinel lymph node (SLN) surgery.
- These trends indicate a shift in surgical practices, with less extensive surgery being performed after NAC, particularly for patients showing node positivity before treatment, reflecting evolving clinical approaches prior to further research outcomes.
Neoadjuvant chemotherapy (NAC) increases rates of successful breast-conserving surgery (BCS) in patients with breast cancer. However, some studies suggest that BCS after NAC may confer an increased risk of locoregional recurrence (LRR). We assessed LRR rates and locoregional recurrence-free survival (LRFS) in patients enrolled on I-SPY2 (NCT01042379), a prospective NAC trial for patients with clinical stage II to III, molecularly high-risk breast cancer.
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