Supplements and inadvertent doping - how big is the risk to athletes.

Despite ongoing improvements to regulatory and manufacturing guidelines, the potential for contaminated nutritional supplements to cause a failed doping test for an athlete remains a concern. Several surveys of supplements available through the internet and at retail have confirmed that many are contaminated with steroids and stimulants that are prohibited for use in elite sport. Suggested responses to this issue include the complete avoidance of all supplements.

The role of banned substance residue analysis in the control of dietary supplement contamination.

The potential for contaminated dietary supplements to result in a failed doping test remains a concern for athletes, trainers, and sporting authorities despite improvements to regulatory guidelines. Previous surveys of readily available supplements confirm that many are contaminated with steroids and stimulants prohibited for use in elite sport. Suggested responses to this issue include the complete avoidance of all supplements.

Influence of delivery mode on the urinary excretion of nandrolone metabolites.

Introduction: This study examined the influence of a supplement matrix on the excretion pattern of nandrolone metabolites in response to ingestion of a trace amount of 19-norandrostenedione.

Methods: Ten male and nine female volunteers (mean ± SD: age = 26 ± 3 yr, height = 1.71 ± 0.

Urinary nandrolone metabolite detection after ingestion of a nandrolone precursor.

Introduction: Quantities of various anabolic/androgenic steroids have been found in dietary supplements without their presence being disclosed on the label. The aim of this study was to quantify the excretion patterns of the diagnostic metabolites, 19-norandrosterone (19-NA), and 19-noretiocholanolone (19-NE) after ingestion of small doses of 19-nor-4-androstene-3,17-dione (19-norandrostenedione).

Methods: Eleven males and nine females entered the laboratory in the morning after an overnight fast.

Typical variability and evaluation of sources of variability in drug dissolution testing.

To investigate variability in dissolution testing an international collaborative study was performed by 29 laboratories. Glibenclamide (glyburide) tablets were used in the investigation in which multipoint dissolution profiles were established using USP paddle apparatus. In contrast to a previous report, the variability of the glibenclamide dissolution data was significantly lower.