Publications by authors named "Catherine J Thiffeault"
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Synopsis of recent research by authors named "Catherine J Thiffeault"
- Catherine J Thiffeault's research predominantly focuses on genotoxicity testing, particularly utilizing the Pig-a gene mutation assay to evaluate the effects of chemicals like ethyl methanesulfonate (EMS) and N-ethyl-N-nitrosourea (ENU) on rat models.
- Thiffeault's studies, including those assessing dose-response relationships and validation efforts for the Pig-a assay, highlight the assay's efficacy in comparing to traditional genotoxicity endpoints, showcasing its potential for rapid identification of mutagenic effects.
- Through collaborative international trials, Thiffeault has contributed to establishing methodology standards for the Pig-a assay, ensuring reproducibility and transferability of results across different laboratories, which is vital for advancing regulatory toxicology.
