BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling.

Objective: Colorectal cancer remains the fourth most common cause of cancer-related mortality worldwide. Here we investigate the role of nuclear factor-κB (NF-κB) co-factor B-cell CLL/lymphoma 3 (BCL-3) in promoting colorectal tumour cell survival.

Design: Immunohistochemistry was carried out on 47 tumour samples and normal tissue from resection margins.