Publications by authors named "Catherine Heinzinger"
Article Synopsis
- The study investigates how different sleep-related symptoms and patterns (phenotypes) relate to the risk of developing atrial fibrillation (AF) over time.
- Researchers analyzed data from over 43,000 patients who underwent sleep studies, identifying five distinct sleep phenotypes and assessing their impact on AF incidence.
- Results showed that specific phenotypes, particularly the hypoxia and apneas + arousals subtypes, significantly increased the risk of developing AF, highlighting the importance of sleep disorders in heart health.
Background: No therapy has been shown to reduce the risk of major adverse cardiovascular events (MACE) and death in patients with obstructive sleep apnea (OSA).
Objectives: The authors sought to investigate the long-term relationship between metabolic surgery and incident MACE in patients with OSA and obesity.
Methods: Adult patients with a body mass index 35 to 70 kg/m and moderate-to-severe OSA at a U.
Article Synopsis
- A large clinical study was conducted at the Cleveland Clinic to investigate the links between sleep-disordered breathing, sleep-related hypoxia, and the development of atrial fibrillation (AF) over a 5-year period.
- The study analyzed data from over 42,000 patients, finding that increased apnea hypopnea index and lower oxygen saturation significantly raised the risk of developing AF.
- The results indicate that sleep-related hypoxia is a critical factor in the onset of AF, remaining significant even after accounting for pulmonary health metrics.
Sleep dysfunction has been identified in the pathophysiology of Alzheimer's disease (AD); however, the role and mechanism of circadian rhythm dysfunction is less well understood. In a well-characterized cohort of patients with AD at the mild cognitive impairment stage (MCI-AD), we identify that circadian rhythm irregularities were accompanied by altered humoral immune responses detected in both the cerebrospinal fluid and plasma as well as alterations of cerebrospinal fluid biomarkers of neurodegeneration. On the other hand, sleep disruption was more so associated with abnormalities in circulating markers of immunity and inflammation and decrements in cognition.
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