Publications by authors named "Catherine Hallam"
Article Synopsis
- Researchers designed new inhibitors for the enzyme cPLA(2) using a specific model that includes a lipophilic anchor, an electrophilic "trap" for serine, and an acidic binding group.
- They tested a series of compounds, focusing on variations in the lipophilic, electrophilic, and acidic groups, which revealed a clear connection between the chemical structure of the inhibitors and their effectiveness.
- The most successful compound, AR-C70484XX, showed remarkable potency as an inhibitor, being over 20 times more effective than a standard inhibitor and demonstrating significant activity in both isolated enzyme assays and in human cells.
