Publications by authors named "Catherine Ferrer"
Background: Letrozole, an aromatase inhibitor metabolised via CYP2A6 and CYP3A4/5 enzymes, is used as adjuvant therapy for women with hormone receptor (HR)-positive early breast cancer. The objective of this study was to quantify the impact of CYP2A6 genotype on letrozole pharmacokinetics (PK), to identify non-adherent patients using a population approach and explore the possibility of a relationship between non-adherence and early relapse.
Methods: Breast cancer patients enrolled in the prospective PHACS study (ClinicalTrials.
The Influence of Surgical Complexity and Center Experience on Postoperative Morbidity After Minimally Invasive Surgery in Gynecologic Oncology: Lessons Learned from the ROBOGYN-1004 Trial.
Ann Surg Oncol
July 2024
Background: This study was a secondary analysis of the ROBOGYN-1004 trial conducted between 2010 and 2015. The study aimed to identify factors that affect postoperative morbidity after either robot-assisted laparoscopy (RL) or conventional laparoscopy (CL) in gynecologic oncology.
Methods: The study used two-level logistic regression analyses to evaluate the prognostic and predictive value of patient, surgery, and center characteristics in predicting severe postoperative morbidity 6 months after surgery.
Article Synopsis
- This study investigates the effects of whole-body cryotherapy (WBC) on joint pain caused by aromatase inhibitors in breast cancer patients, aiming to determine if WBC can alleviate pain better than a placebo treatment.* -
- It is a randomized, double-blind, placebo-controlled clinical trial with 56 participants experiencing significant joint pain, measuring outcomes like pain severity and quality of life at various time points post-treatment.* -
- Ethics approval has been secured, and the findings will be shared in a peer-reviewed journal and at international conferences to inform future treatment approaches.*
Article Synopsis
- * CTCs were found primarily in the ovarian vein samples of 8 out of 10 patients, with no significant differences in the number of CTCs based on age, tumor grade, FIGO stage, or tumor size.
- * The study identified estrogen receptor-positive CTCs and clusters, indicating a need for further research on the potential prognostic and therapeutic implications of CTCs during EC surgery.
Interest of para-aortic lymphadenectomy for locally advanced cervical cancer in the era of PET scanning.
Eur J Obstet Gynecol Reprod Biol
May 2022
Article Synopsis
- The study focuses on evaluating the effectiveness of PET-CT scans for staging lymph nodes in patients with locally advanced cervical cancer (LACC) who underwent treatment with pelvic chemoradiotherapy.
- Researchers analyzed data from 71 patients who had PET-CT scans followed by a surgical procedure called para-aortic lymphadenectomy, assessing the accuracy of the scans through various metrics like sensitivity and specificity.
- The results showed that while the PET-CT had a high specificity (84%) and negative predictive value (93%), its overall sensitivity (55%) and positive predictive value (33%) were lower, suggesting the need for surgical staging in certain high-risk cases despite a negative PET-CT result.
Objective: In gynecologic oncology, minimally invasive surgery using conventional laparoscopy (CL) decreases the incidence of severe morbidity compared to open surgery. In 2005, robot-assisted laparoscopy (RL) was approved for use in gynecology in the US. This study aimed to assess whether RL is superior to CL in terms of morbidity incidence.
View Article and Find Full Text PDFThe objective of our observational prospective study was to investigate the severity and prevalence of urinary and pelvic floor disorders in gynecologic cancer survivors. All patients surviving gynecological cancer in the region as well as women receiving invitations to attend breast-screening checkups as the control population were asked to fill-in questionnaires assessing pelvic prolapse symptoms (PFDI-20, Wexner) and associated quality of life (PFIQ-7). Eighty-nine women were included in the cancer survivor group and 1088 in the control group.
View Article and Find Full Text PDFContext: Empirical evidence suggests that autocrine human GH (hGH) may possess a proliferative and oncogenic role in human mammary carcinoma. However, this concept is largely derived from studies using cultured human mammary carcinoma cell (HMCC) lines.
Objective: We investigated the expression and functionality of hGH and the hGH receptor in isolated cultures of primary HMCC.