Publications by authors named "Catherine Dekeyser"
Phenotyping vestibulocochlear manifestations in Susac syndrome: a cohort study.
Eur Arch Otorhinolaryngol
October 2024
Article Synopsis
- The study aims to understand how the vestibulocochlear system is affected in patients with Susac syndrome (SuS), which is a rare condition that impacts the brain, eyes, and inner ear.
- A review of 21 patient files shows that most experienced various audiovestibular symptoms, including vertigo and sensorineural hearing loss, with specific audiological and vestibular testing revealing common patterns of dysfunction.
- The findings suggest that early treatment with immunosuppressive therapy can help prevent severe audiovestibular problems, indicating the need for more research to understand the underlying causes and improve patient outcomes.
Article Synopsis
- * Machine learning models were applied to predict confirmed disability progression after two years, achieving a ROC-AUC score of 0.71, indicating moderate accuracy, while historical disability was found to be a stronger predictor than treatment or relapse history.
- * The research followed strict guidelines and made its coding accessible for others to facilitate future benchmarking in predicting disability progression in MS patients.
Article Synopsis
- The study investigates the effectiveness of various cerebrospinal fluid (CSF) kappa free light chain (κFLC) measures as diagnostic markers for multiple sclerosis (MS), highlighting discrepancies in cutoff values across two different testing methods.
- A total of 263 participants were analyzed, and results showed significant differences in optimal diagnostic cutoff values and sensitivity rates for the κFLC index, κIgG index, and CSF κFLC/IgG ratio between the two reference centers.
- Both testing methods produced identical results for isolated CSF κFLC, suggesting a reliable benchmark for MS diagnosis, while also indicating that κFLC and κIgG indices offer higher diagnostic performance compared to traditional methods.
Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study.
J Neurol Neurosurg Psychiatry
October 2024
Background: It remains unclear whether routine cerebrospinal fluid (CSF) parameters can serve as predictors of multiple sclerosis (MS) disease course.
Methods: This large-scale cohort study included persons with MS with CSF data documented in the MSBase registry. CSF parameters to predict time to reach confirmed Expanded Disability Status Scale (EDSS) scores 4, 6 and 7 and annualised relapse rate in the first 2 years after diagnosis (ARR2) were assessed using (cox) regression analysis.
Background And Purpose: Susac syndrome (SuS) is a rare, autoimmune, neurological disease characterized by a clinical triad of branch retinal artery occlusion, sensorineural hearing loss and encephalopathy. Neuropsychological functioning in SuS is little researched and the prevalence, nature, and evolution over time of cognitive deficits in SuS remain unclear. This study aimed to better understand the long-term neuropsychological outcomes of patients with SuS.
View Article and Find Full Text PDFSusac syndrome (SuS) is a rare immune-mediated endotheliopathy that affects the brain, retina and inner ear and is characterised by the variable clinical triad of encephalopathy, visual and vestibulocochlear dysfunction. Here, we present clinical and paraclinical data of 19 SuS patients followed at Ghent University Hospital and highlight some atypical clinical and novel radiological findings. Our findings suggest that spinal involvement expands the clinical phenotype of SuS.
View Article and Find Full Text PDFA 49-year-old patient with a history of lymphoproliferation and autoimmune cytopenias presented with unexplained longitudinal extensive transverse myelitis. Flow cytometry on peripheral blood showed an elevated level of double negative T lymphocytes, a finding typical for autoimmune lymphoproliferative syndrome (ALPS). Inborn error of immunity (IEI) gene panel demonstrated a heterozygous variant in the FAS gene (c.
View Article and Find Full Text PDFBackground: Many natalizumab treated patients experience end of dose interval (EDI) symptoms towards the end of the administration cycle. Natalizumab has previously shown to influence cytokine profiles in relapsing remitting MS patients. We hypothesize that EDI symptoms might be explained by variability in serum cytokine levels during natalizumab treatment.
View Article and Find Full Text PDFIntroduction: Repetitive transcranial magnetic stimulation (rTMS) is an established non-invasive neurostimulation technique that is able to induce neuromodulatory effects outlasting the duration of the stimulation train. The cortical excitability disturbance in epilepsy provides a rationale for investigating the efficacy of low-frequency rTMS as a treatment for epilepsy patients. Sofar clinical trials in epilepsy patients have shown conflicting results ranging from ineffective to very effective.
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