Acute cardiac effects of nicotine in healthy young adults.

Background: Nicotine is known to have many physiologic effects. The influence of nicotine delivered in chewing gum upon cardiac hemodynamics and conduction has not been well-characterized.

Methods: We studied the effects of nicotine in nonsmoking adults (6 male, 5 female; ages 23-36 years) using a double-blind, randomized, cross-over study.