Publications by authors named "Catherine Coco"
Article Synopsis
- Merkel cell carcinoma (MCC) is a serious skin cancer linked to the Merkel cell polyomavirus (MCPyV) in 80% of cases, with the remaining 20% associated with UV exposure; both types involve the inactivation of the RB1 gene leading to increased SOX2 expression.
- In a study of 196 MCC tumors, it was found that RB1 loss was present in 27% of MCC cases, indicating a strong correlation with MCPyV-negative status, whereas MCPyV-positive cases remained RB1-positive.
- SOX2 was shown to be a key diagnostic marker, with 92% of MCC tumors expressing it diffusely compared to only 2% in non-neuro
The human kallikrein-related peptidases (KLK) are serine proteases whose concentrations are often abnormal in common human malignancies and contribute to neoplastic progression through multifaceted roles. However, little attention has been paid to their synthesis and involvement in the development and dissemination of lung cancer, the leading cause of cancer mortality worldwide. We have analysed the production of KLK6 in normal lung and tumour tissues from patients with non-small cell lung cancer (NSCLC).
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