Buprenorphine versus methadone in pregnant opioid-dependent women: a prospective multicenter study.

Patients And Methods: In order to investigate the effects of exposure to buprenorphine compared with methadone during pregnancy, a prospective multicenter study was conducted in collaboration with maternity hospitals, maintenance therapy centers, and general practitioners involved in addiction care. Ninety pregnant women exposed to buprenorphine and 45 to metadone were selected for the study.

Results: During pregnancy, some women were exposed to illicit agents: cannabis (42% in the buprenorphine group vs.