Polyautoimmunity manifest as inflammatory myopathy, uveitis, and progressive cutaneous depigmentation in a mixed breed dog: a case report.

Background: Polyautoimmunity is the expression of more than one autoimmune disease in a single patient. This report documents polyautoimmunity in a mixed breed dog with concurrent uveitis, cutaneous depigmentation, and inflammatory myopathy.

Case Presentation: A 1-year-old male neutered mixed breed dog was presented for progressive generalized leukotrichia and leukoderma, bilateral panuveitis, and masticatory muscle atrophy.

Evaluation of aural masses submitted as inflammatory polyps in 20 dogs (2000-2020).

Background: Canine non-neoplastic aural polypoid masses (APMs) are uncommon, with few published studies.

Objectives: The aim of this retrospective study was to characterise the clinical presentation, diagnostic imaging and histopathological results for APMs submitted as aural inflammatory polyps (AIPs).

Animals: Twenty dogs with APMs evaluated at a veterinary teaching hospital.

Retrospective case series: Necrotising fasciitis in 23 dogs.

Background: Necrotising fasciitis (NF) is a rare, rapidly progressive subcutaneous bacterial infection. Few studies have characterised NF in dogs.

Hypothesis/objectives: To retrospectively describe clinical and laboratory findings, with treatments and outcomes, in dogs with NF.

Locally extensive follicular hamartomas with concurrent follicular cysts and dermoid cysts on the head of a dog.

A 5-month-old, male intact Australian shepherd dog was presented with nodular lesions affecting the dorsal head. A locally diffuse form of follicular hamartomas, with concurrent dermoid cysts and follicular cysts, was diagnosed by histopathological examination. Complete surgical excision of the affected skin and closure with a subdermal plexus advancement flap led to long-term resolution.

Pathology in Practice.

In collaboration with the American College of Veterinary Pathologists.

Preliminary study of the stability of dexamethasone when added to commercial veterinary ear cleaners over a 90 day period.

Background: Topical corticosteroids are commonly used in the management of allergic otitis externa to diminish inflammation. A common strategy is to make compounded solutions of dexamethasone in ear cleaner.

Hypothesis/objectives: The objective of this study was to determine the stability of dexamethasone when added to four commercial ear cleaners (ec): designated ecA, ecB, ecC and ecD.

Serum immunoglobulin E responses to aeroallergens in cats with naturally occurring airway eosinophilia compared to unaffected control cats.

Background: Eosinophilic airway disease in cats is sometimes described as allergic in origin, but controversy exists in the documentation of allergy in cats and the utility of allergy testing for respiratory tract diseases.

Objective: To examine serum immunoglobulin E (IgE) response to aeroallergens in cats with airway eosinophilia.

Animals: Fifteen cats with idiopathic eosinophilic airway inflammation and 9 control cats.

Open trial of Bruton's tyrosine kinase inhibitor (PRN1008) in the treatment of canine pemphigus foliaceus.

Background: Bruton's tyrosine kinase (BTK) is important in B-cell signalling. Efficacy has been reported for BTK inhibitors (BTKi) in human autoimmune diseases. Canine pemphigus foliaceus (cPF) is one of the most common canine autoimmune skin diseases.

A case of atypical multifocal nodular eosinophilic dermatosis in a Labrador retriever dog.

Background: A dog with gastrointestinal signs and a history of administration of multiple drugs developed acute multifocal to coalescing ulcerative nodules and a large plaque.

Objective: To describe abnormal nodular clinical lesions with an unexpected superficial and deep severe eosinophilic perivascular to interstitial inflammation.

Animal: A 7-year-old spayed female Labrador retriever METHODS AND MATERIALS: Blood tests, faecal and urinalysis, and abdominal radiographs were performed; skin biopsy samples were taken for cytological, culture and histopathological analyses.

Multicentric B-cell lymphoma with presumed paraneoplastic generalized cutaneous sclerosis in a dog.

Background: Reports of dermal sclerosis in dogs include scleroderma or morphea of unknown cause, cicatricial alopecia and congenital/hereditary fibrosis.

Clinical Summary: A 12-year-old, male castrated chihuahua-mix dog was evaluated for skin lesions of unknown duration. The dog had severe alopecia, skin thickening and marked peripheral lymphadenopathy.

Efficacy of a Bruton's Tyrosine Kinase Inhibitor (PRN-473) in the treatment of canine pemphigus foliaceus.

Background: Bruton's tyrosine kinase (BTK) is important in B-cell signalling. Efficacy has been reported for BTK inhibitors (BTKi) in human autoimmune diseases. Canine pemphigus foliaceus (cPF) is the most common canine autoimmune skin disease.

Clinicopathological findings and clinical outcomes in 49 cases of feline pemphigus foliaceus examined in Northern California, USA (1987-2017).

Background: Few studies have described the pathophysiology, clinical course, treatment outcomes and quality of life (QoL) of cats with pemphigus foliaceus (PF).

Objective: Describe clinicopathological features, treatment outcomes and impacts on QoL in feline PF.

Animals: Forty-nine client-owned cats with PF that presented to a veterinary teaching hospital between 1987 and 2017.

An unresponsive progressive pustular and crusting dermatitis with acantholysis in nine cats.

Background: Between 2000 and 2012, nine cats were examined with a visually distinctive, progressive crusting dermatitis that was poorly responsive to all attempted therapies.

Objectives: Documentation of clinical and histopathological findings of this disease.

Animals: Nine privately owned cats.

Alopecia universalis in a dog with testicular neoplasia.

Objective: To describe a case of testicular neoplasia and alopecia universalis in a dog, and successful treatment of the latter with ciclosporin.

Animal: Twelve-year-old intact male wirehaired fox terrier.

Methods: Castration, skin biopsy for histopathology, lymphocyte immunophenotyping and clonality analysis of the canine T-cell receptor gamma locus (TCRγ) rearrangement.

Localized parakeratotic hyperkeratosis in sixteen Boston terrier dogs.

Background: Although zinc responsive dermatosis is typically a disorder of Arctic breed dogs, this study identifies similar cutaneous lesions on the face and pressure points of Boston terrier dogs.

Hypothesis/objectives: To document the clinical and histological features of localized parakeratotic hyperkeratosis of Boston terrier dogs, to determine if the lesions respond to zinc supplementation and to determine whether tissue zinc levels were decreased in affected versus unaffected dogs.

Material And Methods: Sixteen Boston terrier dogs with similar gross and histological findings were identified retrospectively from two institutions.

Oral administration of famciclovir for treatment of spontaneous ocular, respiratory, or dermatologic disease attributed to feline herpesvirus type 1: 59 cases (2006-2013).

OBJECTIVE To evaluate outcomes for cats treated with orally administered famciclovir 3 times/d for clinical signs attributed to naturally occurring feline herpesvirus type 1 (FHV-1) infection and to assess variables related to owner satisfaction with the treatment. DESIGN Retrospective case series. ANIMALS 59 client-owned cats.

A retrospective review of hyperaesthetic leucotrichia in horses in the USA.

Background: Hyperaesthetic leucotrichia (HL) rarely affects horses and causes painful lesions on the dorsum that result in leucotrichia. This may be a variant of erythema multiforme (EM), but there are no studies investigating this condition.

Objectives: Describe the clinical and histological features of HL and compare them to the histological features of EM.

Aspergillus otitis in small animals--a retrospective study of 17 cases.

Background: Aspergillus spp. are saprophytic opportunistic fungal organisms and are a common cause of otomycosis in humans. Although there have been case reports of Aspergillus otitis externa in dogs, to the best of the authors' knowledge, this is the first retrospective case series describing Aspergillus otitis in dogs and cats.

Canine sterile nodular panniculitis: a retrospective study of 39 dogs.

Background: Canine sterile nodular panniculitis (SNP) is an inflammatory disease of the panniculus that is typically managed with immunomodulatory or immunosuppressive treatments. It has been reported to be a cutaneous marker of an underlying systemic disease.

Hypothesis/objectives: To assess the presence or absence of concurrent systemic diseases associated with canine SNP and to document breed predispositions.

Malassezia spp on the periocular skin of dogs and their association with blepharitis, ocular discharge, and the application of ophthalmic medications.

Objective: To determine how frequently Malassezia spp were identified on the periocular skin of dogs and assess the respective associations between the presence of Malassezia spp on the periocular skin and blepharitis, ocular discharge, and the application of ophthalmic medications.

Design: Prospective clinical study.

Animals: 167 eyelids of 84 dogs.

Skin diseases in pet rabbits: a retrospective study of 334 cases seen at the University of California at Davis, USA (1984-2004).

Background: Rabbits are growing in popularity as companion animals, and dermatology problems are often the presenting complaint when seeing a veterinarian.

Hypothesis/objectives: To document skin diseases and their prevalence in pet domestic rabbits (Oryctolagus cuniculus) in northern California, USA; to investigate predilections for breed, age or sex for the most common conditions over a 20 year period.

Animals: Three hundred and thirty-four pet rabbits from the overall hospital population met inclusion criteria.