Publications by authors named "Catherine A Hooker"
Background & Aims: We assessed the diagnostic performance of magnetic resonance imaging (MRI) proton density fat fraction (PDFF) in grading hepatic steatosis and change in hepatic steatosis in adults with nonalcoholic steatohepatitis (NASH) in a multi-center study, using central histology as reference.
Methods: We collected data from 113 adults with NASH participating in a multi-center, randomized, double-masked, placebo-controlled, phase 2b trial to compare the efficacy cross-sectionally and longitudinally of obeticholic acid vs placebo. Hepatic steatosis was assessed at baseline and after 72 weeks of obeticholic acid or placebo by liver biopsy and MRI (scanners from different manufacturers, at 1.
Article Synopsis
- The study aimed to evaluate and compare the effectiveness of two MRI techniques (magnitude-based and complex-based) in measuring liver fat content in children, using MR spectroscopy as a reference.
- A total of 200 children underwent MRI exams, which included both techniques and a special MRS method, allowing for detailed assessment of liver fat in different segments.
- The results showed both MRI methods were accurate and consistent with MRS findings, indicating reliable measurements of liver fat content with minimal differences between the two MRI techniques.
Purpose: To investigate the regional variability of adipose tissue triglyceride composition in vivo using H MRS, examining potential confounders and corrections for artifacts, to allow for adipose tissue spectrum estimation.
Materials And Methods: H magnetic resonance (MR) stimulated echo acquisition mode (STEAM) spectra were acquired in vivo at 3T from 340 adult patients (mean age 48.9 years, range 21-79 years; 172 males, 168 females; mean body mass index [BMI] 34.
Purpose: To examine the reproducibility of quantitative magnetic resonance (MR) methods to estimate hepatic proton density fat-fraction (PDFF) at different magnetic field strengths.
Materials And Methods: This Health Insurance Portability and Accountability Act (HIPAA)-compliant study was approved by the Institutional Review Board. Following informed consent, 25 severely obese subjects (mean body mass index [BMI]: 45 ± 4, range: 38-53 kg/m(2) ) were scanned at 1.