Publications by authors named "Cathelijne van Zelst"
Article Synopsis
- Symptoms of asthma and COPD can be similar, and patients may have both conditions simultaneously, indicating a need for better assessment tools.
- The study aimed to develop a new questionnaire by combining the asthma control questionnaire (ACQ) and the clinical COPD questionnaire (CCQ) to evaluate disease burden across all obstructive lung diseases.
- Using data from various patient cohorts, researchers identified nine key questions through Principal Component Analysis (PCA), leading to the proposed "Obstructive Lung Disease Questionnaire" for more effective disease assessment.
Article Synopsis
- The study investigates the differences in innate lymphoid cell (ILC) populations, specifically ILC1s and ILC2s, between patients with COPD (Chronic Obstructive Pulmonary Disease), asthma, and control groups.
- Results show significantly higher levels of inflammatory CD4 ILC1s and lower levels of CD117 ILC2s in COPD patients compared to asthma patients, highlighting distinct inflammatory profiles.
- These findings could help in understanding the mechanisms of COPD and asthma, potentially aiding in better patient classification and treatment strategies.
Article Synopsis
- The study investigates the relationship between clustering analyses of COPD and the GOLD ABCD classification, focusing on whether new behavioral factors influence clustering outcomes.
- It found that while certain clusters aligned with the GOLD groups, the previously established clinical phenotypes couldn't be replicated in a new patient population.
- The inclusion of new variables like quality of life and daily activities led to the formation of distinct clusters, suggesting that using cluster analysis for identifying COPD phenotypes may not effectively guide individual treatment strategies.
Article Synopsis
- Dupilumab, an add-on treatment for severe uncontrolled asthma, shows strong effectiveness and safety based on a real-world study involving 148 patients over 12 months.
- Key findings include a significant decrease in the annual exacerbation rate from 4.00 to 1.00, reduced oral corticosteroid dependency, and improved asthma control and pulmonary function.
- While adverse events were noted in 45.3% of patients, headache being the most common, overall results mirror those of previous phase-III trials, suggesting dupilumab could be a beneficial option in managing severe uncontrolled asthma.
Article Synopsis
- Adult-onset asthma (AoA) tends to be more severe than childhood onset asthma (CoA), and this study explored the links between AoA and metabolic conditions, particularly obesity.
- The research involved a comparison of metabolic syndrome and inflammatory markers among patients with AoA, CoA, and healthy controls, using a group of 81 participants from outpatient clinics in Rotterdam.
- Results showed that AoA was significantly linked to metabolic syndrome, with higher levels of inflammatory markers like IL-6 and leptin-adiponectin in AoA patients, suggesting that inflammation related to fat tissue may contribute to the severity of AoA.
Article Synopsis
- * Involving 1006 patients, the research found that 17% experienced acute hyperventilation, and 23% had chronic hyperventilation, with chronic cases more frequent in younger females with better lung function.
- * The conclusion notes that hyperventilation is prevalent in stable asthma patients, but the NQ is not a reliable tool for detecting hyperventilation in this group.
Article Synopsis
- Asthma attacks in adults can be triggered by respiratory infections, and there's interest in using bacterial lysates to help manage these attacks.
- A study was conducted with 75 adults with severe asthma, where they received either a bacterial lysate (OM-85) or a placebo over six months to see if it would reduce asthma exacerbations and improve lung function.
- Results showed no significant difference in asthma attack frequency between the two groups after 18 months, but there was an improvement in lung function and a lower detection rate of viruses during infections in the OM-85 group.
Article Synopsis
- Adults with high BMI are at a greater risk for developing asthma, prompting a study on the link between lipid levels and inflammation in patients with asthma and obesity.
- The research included 96 asthma patients and 45 controls, examining their lipid levels, neutrophils, and eosinophils across a broad BMI range.
- Findings revealed that patients with obesity and asthma had significantly higher serum triglycerides, suggesting that elevated triglycerides might be an overlooked factor contributing to asthma development, though causation was not established.
Article Synopsis
- Ehealth platforms are increasingly vital for supporting self-management in COPD patients, especially during the COVID-19 pandemic; this study examines how healthcare professional involvement affects patients' adherence to such platforms.
- The research involved 299 COPD patients, analyzing their usage of the Curavista eHealth platform, comparing those using it independently to those in a blended setting with professional support.
- Results indicated that patients in a blended setting submitted questionnaire responses 3.25 times more frequently, with hospital care showing even higher adherence compared to primary care, highlighting the importance of blended care for effective self-management in COPD.
Background: Several characteristics of the metabolic syndrome, such as obesity and hypertension, have emerged as risk factors for a poor clinical outcome in COVID-19. However, most reports lack data on the metabolic syndrome itself. This study investigated prospectively the relationship between respiratory deterioration and the presence of metabolic syndrome or abdominal adiposity in patients with COVID-19.
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