Reflectance Confocal Microscopy Assessment of the Depigmenting Agents Complex for Melasma Treatment.

The management of melasma remains a challenge in dermatology, despite the availability of a variety of therapies, such as sunscreens, hypopigmented topical treatments, and chemical peels. The ideal treatment for melasma should be efficient, conclusive, and free from side effects. The aim of this study is to assess the efficacy and tolerability of a depigmenting agent complex, based on the synergy of oligopeptide-68, phytic acid, glycolic acid, lactic acid, and octinoxate measured by clinical and reflectance confocal microscopy outcomes in melasma patients.