Goal setting as part of a holistic intervention to promote independence in older people with mild frailty: a process evaluation alongside a randomised controlled trial.

Background: Frailty is a condition resulting from a decline in physiological reserves caused by an accumulation of several deficits, which progressively impairs the ability to recover from health adverse events. Following a promising feasibility study, the HomeHealth trial assessed a holistic tailored intervention for older adults with mild frailty to promote independence in their own homes, compared with usual care. We aimed to understand how goal setting worked among older people with mild frailty.

The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester-A primary cohort study with a scoping review.

Introduction: Supine sleep position is associated with stillbirth, likely secondary to inferior vena cava compression, and a reduction in cardiac output (CO) and uteroplacental perfusion. Evidence for the effects of prone position in pregnancy is less clear. This study aimed to determine the effect maternal prone position on maternal haemodynamics and fetal heart rate, compared with left lateral position.

Impact of Visual Barrier Removal on the Behavior of Shelter-Housed Dogs.

With millions of dogs housed in shelters each year, it is important to consider how the shelter environment impacts welfare. Social isolation and a lack of control over the environment can negatively impact wellbeing. However, providing social opportunities requires costly resources and can raise concerns about increased barking.

Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness.

MGA, a transcription factor and member of the MYC network, is mutated or deleted in a broad spectrum of malignancies. As a critical test of a tumor suppressive role, we inactivated in two mouse models of non-small cell lung cancer using a CRISPR-based approach. MGA loss significantly accelerated tumor growth in both models and led to de-repression of non-canonical Polycomb ncPRC1.

deletion destabilizes MYC protein and abrogates Eµ- lymphomagenesis.

Although MAX is regarded as an obligate dimerization partner for MYC, its function in normal development and neoplasia is poorly defined. We show that B-cell-specific deletion of has a modest effect on B-cell development but completely abrogates Eµ-driven lymphomagenesis. While loss affects only a few hundred genes in normal B cells, it leads to the global down-regulation of -activated genes in premalignant Eµ- cells.

Patient and professional engagement in the procurement of dental services.

Objective: To describe the process of patient and professional engagement in the procurement of a specialist dental service. Stakeholder engagement is the practice of interacting with, and influencing, project stakeholders to the overall benefit of the project and its advocates. The successful completion of a project usually depends on how the stakeholders view it.

Sunrise alarm clock for the hearing impaired - biomed 2011.

The Sunrise Alarm Clock is a device designed to be more effective than standard alarm clocks and more pleasant than specialty devices in waking the hearing impaired. This is accomplished with the inclusion of visual, physical, and audio alarms. The visual alarm stimulus is created by manipulating the light output of a bedside lamp to mimic the sunrise.

Dose-response effects of diclazuril against pathogenic species of ovine coccidia and the development of protective immunity.

Twin lambs at pasture with their ewes, were divided into seven groups of 10 lambs. One group of 10 lambs served as a non-infected, untreated control. Five groups of 10 lambs were infected with 10,000 oocysts of Eimeria crandallis and 10,000 oocysts of Eimeria ovinoidalis when they were 3 weeks old (day 21 of the study).

Histopathological observations on the activity of diclazuril (Vecoxan) against the endogenous stages of Eimeria crandallis in sheep.

Doses of sporulated oocysts of Eimeria crandallis were administered to 60 housed lambs aged 3-4 weeks that had been raised coccidia-free. Thirty of the lambs were medicated with diclazuril at intervals over a 20-day period post-infection with the remaining lambs serving as untreated controls. Lambs were euthanased between 5 and 22 days post-infection (dpi) and sections of the small intestine and caecum examined histologically.

A new method for the experimental production of necrotic enteritis and its use for studies on the relationships between necrotic enteritis, coccidiosis and anticoccidial vaccination of chickens.

A new method for the experimental production of necrotic enteritis in chickens is described. The main features are the use of a diet high in wheat and fish meal content; oral administration of a non-lethal inoculum of the coccidium Eimeria maxima followed 6 days later by the bacterium Clostridium perfringens type A per cloaca, so that the bacterial inoculum is deposited at the time and place when and where the intestinal coccidial lesions are maximal; grading of coccidial and clostridial lesions in individual birds sampled during the 14 days following the coccidial infection. The new method was used to examine the relationship between clostridial and coccidial infections.

A novel method for counting eimerian oocysts at very low concentrations in aqueous suspensions.

A novel method for counting eimerian oocysts in samples of drinking water has been developed to fulfil the need for monitoring the delivery of very low concentrations of live anticoccidial vaccines to poultry via pipeline nipple-drinker systems. Advantages of the method are the ease of sample collection and processing, high degrees of accuracy and precision, and a sensitivity of one oocyst ml(-1). Results of a validation test are presented, with a protocol for the method and notes on its use.

The nitroreductase/CB1954 combination in Epstein-Barr virus-positive B-cell lines: induction of bystander killing in vitro and in vivo.

Epstein-Barr virus (EBV)-based gene delivery vectors that preferentially express toxic genes in EBV-infected cells could be used to target EBV-positive tumors for destruction. We have shown previously that the cytosine deaminase (CD) enzyme, which converts the prodrug 5-fluorocytosine (5-FC) into the toxic compound 5-fluorouracil efficiently kills EBV-positive cells in the presence of 5-FC, with a substantial bystander killing effect in vitro and in vivo. To identify the optimal enzyme/prodrug combination for treating EBV-positive lymphomas, we have compared the effectiveness of the CD/5-FC combination with the nitroreductase (NTR)/CB1954 combination for killing EBV-positive B-cell lines.

A new protocol for a challenge test to assess the efficacy of live anticoccidial vaccines for chickens.

The search for vaccines to control coccidioses caused by Eimeria species in chickens (Gallus gallus) is intensifying because of the increasing threat of drug resistance to anticoccidial agents. It is important, therefore, to develop a reliable standard method for the assessment of multivalent vaccine efficacy, because many criteria generally used to judge drug efficacy are not appropriate for vaccines. The lack of correlations between oocyst production, severity of lesions and bird weight gains is discussed.

The pathogenesis of experimental infections of Cryptosporidium muris (strain RN 66) in outbred nude mice.

Three groups of six-week-old nude outbred mice were orally infected with 400, 20,000 and 1,000,000 oocysts of Cryptosporidium muris (strain RN 66) per mouse, respectively. Oocysts were detected in the faeces from 10-18 days post-infection (p.i.