Publications by authors named "Catarina T Pinho"
Despite all the efforts acquired in four years of the COVID-19 pandemic, the path to a full understanding of the biological mechanisms involved in this disease remains complex. This is partly due to a combination of factors, including the inherent characteristics of the infection, socio-environmental elements, and the variations observed within both the viral and the human genomes. Thus, this study aimed to investigate the correlation between genetic host factors and the severity of COVID-19.
View Article and Find Full Text PDFIntroduction: After three years since the beginning of the pandemic, the new coronavirus continues to raise several questions regarding its infectious process and host response. Several mutations occurred in different regions of the genome, such as in the spike gene, causing the emergence of variants of concern and interest (VOCs and VOIs), of which some present higher transmissibility and virulence, especially among patients with previous comorbidities. It is essential to understand its spread dynamics to prevent and control new biological threats that may occur in the future.
View Article and Find Full Text PDFArticle Synopsis
- Circulating tumor DNA (ctDNA) is a new, less invasive method used in precision medicine to analyze genetic materials shed by tumors into the bloodstream.
- ctDNA can help tailor patient treatment by revealing tumor evolution and genetic changes, assisting in patient stratification, monitoring responses to therapy, and identifying early intervention opportunities.
- The review discusses how ctDNA analysis can guide personalized treatment decisions for various cancers, including melanoma, castration-resistant prostate cancer, breast cancer, metastatic colorectal cancer, and non-small cell lung cancer.