Publications by authors named "Catarina Pinto Silva"
Unlabelled: Respiratory alkalosis is associated with central nervous system (CNS) diseases, drugs, lung diseases and others. Safinamide is a recent anti-parkinsonian drug with anti-dyskinetic properties and a good adjunct to L-dopa therapy during the activation period, with no significant adverse effects described. The authors present a case of a 71-year-old woman, with Parkinson's disease treated with levodopa/benserazide, safinamide, amitriptyline, sertraline and diazepam.
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- The study aimed to assess how the Pavlik Harness treatment affects motor skills development in children with Developmental Dysplasia of the Hip, compared to a healthy control group.
- A total of 121 children participated, consisting of 55 with the hip condition and 66 healthy children, with a focus on the timing of achieving three key motor milestones: sitting, crawling, and walking.
- Results showed that while children with the hip condition reached these milestones about a month later than healthy peers, the differences were not statistically significant, leading to the conclusion that the treatment does not cause major delays in motor skills development.
Lower Limb Edema Caused by Metastatic Signet Ring Cell Stomach Cancer.
Eur J Case Rep Intern Med
August 2023
Unlabelled: Overall gastric cancer incidence is decreasing, but incidence of gastric signet ring cell carcinoma has been rising. The diagnosis can be challenging. It has a poorer prognosis because it tends to be diagnosed at advanced stages.
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- Obesity in prepubertal children may disrupt cardiac rhythms, specifically circadian and ultradian patterns, which has been largely overlooked in research.
- A study involving 316 children showed that overweight/obese kids had a higher frequency of non-dipping blood pressure patterns and lower prevalence of 24-hour mean arterial pressure rhythmicity and heart rate rhythmicity compared to their normal-weight peers.
- The findings indicate potential early signs of cardiovascular issues in obese children, suggesting that further research is necessary to clarify the long-term effects of these disruptions.
Cystic fibrosis (CF), a life-limiting chronic disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) gene, affects more than 90,000 people worldwide. Until recently, the only available treatments were directed to symptom control, but they failed to change the course of the disease. New drugs developed in the last decade have the potential to change the expression, function, and stability of CFTR protein, targeting the basic molecular defect.
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