Experimental Inoculation of and and Its Impact on Alveolar Bone Loss and Oral and Gut Microbiomes.

Oral bacteria are implicated not only in oral diseases but also in gut dysbiosis and inflammatory conditions throughout the body. The periodontal pathogen () often occurs in complex oral biofilms with (), and this interaction might influence the pathogenic potential of this pathogen. This study aims to assess the impact of oral inoculation with , , and their association (+) on alveolar bone loss, oral microbiome, and their potential effects on intestinal health in a murine model.

LA-5 Ameliorates Inflammation and Alveolar Bone Loss Promoted by and in Mice and Impacts Oral and Gut Microbiomes.

The benefits of probiotics on dysbiotic microbiomes and inflammation are dependent on the tested strain, host factors, and the resident microbiome. There is limited knowledge on the effects of probiotics in -associated periodontitis. Thus, LA5 (LA5) was orally inoculated for 30 days in C57Bl/6 mice infected with JP2 (Aa) and (Sg).