Optimizing breathlessness management in amyotrophic lateral sclerosis: insights from a comprehensive systematic review.

Background: Breathlessness is a prevalent symptom affecting the quality of life (QOL) of Amyotrophic Lateral Sclerosis (ALS) patients. This systematic review explored the interventions for controlling breathlessness in ALS patients, emphasizing palliative care (PALC), non-invasive ventilation (NIV), opioids, and non-pharmacological strategies.

Methods: A comprehensive search of PubMed, Cochrane Library, and Web of Science databases was conducted.