Publications by authors named "Catarina B Soares"
Article Synopsis
- Ischemic stroke increases blood-brain barrier permeability and releases markers indicating axonal damage and inflammation, including neurofilament light chain (NF-L) and other inflammatory markers.
- A study measured levels of NF-L and related markers in patients with acute ischemic stroke or transient ischemic attack (TIA) to evaluate their diagnostic and prognostic value, finding that NF-L levels were significantly higher in stroke patients.
- Elevated NF-L levels were linked to poorer clinical outcomes, indicating that plasma NF-L is a potential biomarker for assessing stroke severity and long-term recovery.
Neurofilaments (NFs) are quickly becoming the biomarkers of choice in the field of neurology, suggesting their use as an unspecific screening marker, much like the use of elevated plasma C-reactive protein (CRP) in other fields. With sensitive techniques being readily available, evidence is growing regarding the diagnostic and prognostic value of NFs in many neurological disorders. Here, we review the latest literature on the structure and function of NFs and report the strengths and pitfalls of NFs as markers of neurodegeneration in the context of neurological diseases of the central and peripheral nervous systems.
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