In Vitro and In Silico Cytotoxic Activity of Isocordoin from Against Cancer Cells.

This study investigates the anticancer potential of isocordoin, a prenylated chalcone found in . In vitro assays on colorectal (HT-29), breast (MCF-7) and prostate (PC-3) cancer cell lines, together with a non-cancerous colon cell line (CoN CCD841), revealed that isocordoin is cytotoxic, with PC-3 and MCF-7 cells showing the highest sensitivity. The selectivity index was higher for PC-3 (5.

[Normal values of 6-minute walk test in healthy children and adolescents: A systematic review and meta-analysis].

Introduction: The 6-minute walk test (SMWT) is a submaximal exercise test widely used in the clinical setting, which allows the assessment of physical capacity in healthy and chronic children. For a proper interpretation of SMWT it is necessary to compare the value obtained by the patient with a normal value appropriate for the studied population. The aim of this study was to analyze the normal values of SMWT, in order to establish grouped normal values and to evaluate their association with anthropometric and racial variables in healthy children and adolescents.