Occlusal effects on text reading: an eye-tracker study.

Introduction: Asymmetric electromyographic (EMG) activity during teeth clenching has been linked to cognitive impairment, as evaluated by the Spinnler-Tognoni matrices test, and to asymmetric pupil size (anisocoria). Anisocoria indicates an asymmetric Locus Coeruleus activity, leading to an asymmetric hemispheric excitability worsening cognitive performance. Bite splint wearing corrects EMG asymmetry, reduces anisocoria and improves cognitive performance.

A New Method to Design and Manufacture a Low-Cost Custom-Made Template for Mandible Cut and Repositioning Using Standard Plates in BSSO Surgery.

In this study, a new methodology for designing and creating a custom-made template for maxillofacial surgery has been developed. The custom-made template can be used both for cutting and repositioning of the mandible arches for executing a BSSO (bilateral sagittal split osteotomy) treatment. The idea was developed in order to give the possibility of using a custom-made template with standard plates, thus reducing long times, high costs and low availability of custom-made plates; this represents the proof of novelty of the proposed template, based on a well-established methodology.

Estimating Formant Frequencies of Vowels Sung by Sopranos Using Weighted Linear Prediction.

This study introduces the weighted linear prediction adapted to high-pitched singing voices (WLP-HPSV) method for accurately estimating formant frequencies of vowels sung by lyric sopranos. The WLP-HPSV method employs a variant of the WLP analysis combined with the zero-frequency filtering (ZFF) technique to address specific challenges in formant estimation from singing signals. Evaluation of the WLP-HPSV method compared to the LPC method demonstrated its superior performance in accurately capturing the spectral characteristics of synthetic /u/ vowels and the /a/ and /u/ natural singing vowels.

Trigeminal Stimulation and Visuospatial Performance: The Struggle between Chewing and Trigeminal Asymmetries.

Chewing improves visuospatial performance through locus coeruleus (LC) activation. The effects of bilateral and unilateral mastication were investigated in subjects showing different degrees of asymmetry in masseter electromyographic (EMG) activity during clenching and in pupil size at rest (anisocoria), which is a proxy of LC imbalance. Correlations between performance changes and asymmetry values were found in males, but not in females.

[Recovery of unilateral spatial neglect after stroke over the time].

Unilateral spatial neglect (USN) can have severe functional consequences for patients. Many rehabilitation tools have been proposed in the literature, but only a few well-controlled systematic studies are available. Also, there is no consensus on the effectiveness of these rehabilitation techniques.

Sustainable Soil Management: Effects of Clinoptilolite and Organic Compost Soil Application on Eco-Physiology, Quercitin, and Hydroxylated, Methoxylated Anthocyanins on .

Climate change and compostinS1g methods have an important junction on the phenological and ripening grapevine phases. Moreover, the optimization of these composting methods in closed-loop corporate chains can skillfully address the waste problem (pomace, stalks, and pruning residues) in viticultural areas. Owing to the ongoing global warming, in many wine-growing regions, there has been unbalanced ripening, with tricky harvests.

Unraveling the Link between Interferon-α and Systemic Lupus Erythematosus: From the Molecular Mechanisms to Target Therapies.

Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease with a wide range of clinical expressions. The kidney is often affected, usually within 5 years of the onset of SLE, and lupus nephropathy (LN) carries a high risk for increased morbidity. The clinical heterogeneity of the disease is accompanied by complex disturbances affecting the immune system with inflammation and tissue damage due to loss of tolerance to nuclear antigens and the deposition of immune complexes in tissues.

Leaf Eco-Physiological Profile and Berries Technological Traits on Potted L. cv Pinot Noir Subordinated to Zeolite Treatments under Drought Stress.

In Mediterranean areas, extreme weather conditions such as high diurnal temperatures during the growing season could tweak vine physiology and metabolism, affecting grapes' quality. Moreover, uncertainty in spatial and temporal distribution precipitation is an issue for the water resources of the vineyards, forcing the winemakers to continuously face an increasing water demand in recent decades, which has led them to non-sustainable choices for ambient (i.e.

History of Preeclampsia in Patients Undergoing a Kidney Biopsy: A Biphasic, Multiple-Hit Pathogenic Hypothesis.

Introduction: It is not fully elucidated whether preeclampsia (PE) is a marker or a cause of chronic kidney disease (CKD). To test the hypothesis of a biphasic relationship between PE and CKD, we assessed PE prevalence in women who underwent a kidney biopsy.

Methods: This retrospective, observational study recruited patients who underwent a kidney biopsy after delivery in 2014 to 2019 in 3 Italian Centers (Cagliari, Bari, Messina); low-risk pregnancies observed in Cagliari served as controls.

Biostimulants in Viticulture: A Sustainable Approach against Biotic and Abiotic Stresses.

Climate change and disproportionate anthropogenic interventions, such as the excess of phytopharmaceutical products and continuous soil tillage, are jeopardizing viticulture by subjecting plants to continuous abiotic stress. One of the main physiological repercussions of abiotic stress is represented by the unbalanced redox homeostasis due to the overproduction of reactive oxygen species (ROS), ultimately leading to a state of oxidative stress (detrimental to grape quality). To these are added the direct and indirect damages caused by pathogens (biotic stresses).

Chewing and Cognitive Improvement: The Side Matters.

Chewing improves cognitive performance, which is impaired in subjects showing an asymmetry in electromyographic (EMG) masseter activity during clenching. In these subjects, the simultaneous presence of an asymmetry in pupil size (anisocoria) at rest indicates an imbalance in Ascending Reticular Activating System (ARAS) influencing arousal and pupil size. The aim of the present study was to verify whether a trigeminal EMG asymmetry may bias the stimulating effect of chewing on cognition.

Modeling Carbon Balance and Sugar Content of under Two Different Trellis Systems.

Environmental factors might influence the carbon balance and sugar content in grapevine. In this two-year research, the STELLA software was employed to predict dry matter accumulation in Sangiovese vines, comparing the traditional vertical shoot positioning (VSP) and the single high wire (SHW) trellis systems. Every week, vegetative, eco-physiological and grape quality parameters were collected for 15 tagged vines per trellis system to set up the software.

Effects of Defoliation at Fruit Set on Vine Physiology and Berry Composition in Cabernet Sauvignon Grapevines.

Grapevine canopy defoliation is a fundamentally important technique for the productivity and quality of grapes. Leaf removal is a pivotal operation on high-density vines which aims to improve air circulation, light exposure, and leaf gas exchange. The effects of leaf removal (LR) on vine physiology and berry composition in Cabernet Sauvignon grapevines were studied during the 2018-2019 growing season in the Bolgheri area, Tuscany, Italy.

Thalamocortical Spectral Transmission Relies on Balanced Input Strengths.

The thalamus is a key element of sensory transmission in the brain, as it gates and selects sensory streams through a modulation of its internal activity. A preponderant role in these functions is played by its internal activity in the alpha range ([8-14] Hz), but the mechanism underlying this process is not completely understood. In particular, how do thalamocortical connections convey stimulus driven information selectively over the back-ground of thalamic internally generated activity? Here we investigate this issue with a spiking network model of feedforward connectivity between thalamus and primary sensory cortex reproducing the local field potential of both areas.

The path from trigeminal asymmetry to cognitive impairment: a behavioral and molecular study.

Trigeminal input exerts acute and chronic effects on the brain, modulating cognitive functions. Here, new data from humans and animals suggest that these effects are caused by trigeminal influences on the Locus Coeruleus (LC). In humans subjects clenching with masseter asymmetric activity, occlusal correction improved cognition, alongside with reductions in pupil size and anisocoria, proxies of LC activity and asymmetry, respectively.

A Novel Source-Filter Stochastic Model for Voice Production.

The novel stochastic model to produce voiced sounds proposed in this paper uses the source-filter Fant theory to generate voice signals and, consequently, it does not consider the coupling between the vocal tract and the vocal folds. Two novelties are proposed in the paper. The first one is the new model obtained from the unification of two other deterministic one mass-spring-damper models obtained from the literature and the second one is to build a stochastic model which can generate and control the level of jitter resulting even in hoarse voice signals or with pathological characteristics but using a simpler model than those ones discussed in the literature.

Effects of Extract on Physiology and Berry Traits in .

Several advantages on physiology, productivity, and grape quality have been reported for grapevine treated with seaweed extracts, but little is known about the importance of cyanobacterial-based biostimulants in viticulture. The purpose of this pioneering work was to analyze the broad-spectrum effects of the F&M-C256 extract on L. cv.

Trigeminal input, pupil size and cognitive performance: From oral to brain matter.

It has been observed that, in patients affected by temporomandibular disorders (TMDs) and edentulism, a left-right asymmetry in electromyographic (EMG) activity of masseter muscles during clenching and in pupil size at rest (anisocoria) is present. Both are greatly reduced by an orthotic-prosthetic correction. In parallel, the correction significantly improves cognitive performance.

Spherical-harmonics mode decomposition of neural field equations.

Large-scale neural networks can be described in the spatial continuous limit by neural field equations. For large-scale brain networks, the connectivity is typically translationally variant and imposes a large computational burden upon simulations. To reduce this burden, we take a semiquantitative approach and study the dynamics of neural fields described by a delayed integrodifferential equation.

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation.

Current scientific literature provides evidence that trigeminal sensorimotor activity associated with chewing may affect arousal, attention, and cognitive performance. These effects may be due to widespread connections of the trigeminal system to the ascending reticular activating system (ARAS), to which noradrenergic neurons of the locus coeruleus (LC) belongs. LC neurons contain projections to the whole brain, and it is known that their discharge co-varies with pupil size.

Positron Emission Tomography Can Support the Diagnosis of Dialysis-Related Amyloidosis.

Background: The improvements in dialysis have not eliminated long-term problems, including dialysis-related amyloidosis (DRA), caused by Beta-2 microglobulin deposition. Several types of scintigraphy have been tested to detect DRA, none entered the clinical practice. Aim of the study was to assess the potential of PET-FDG scan in the diagnosis of DRA.

Integrate-and-fire network model of activity propagation from thalamus to cortex.

The thalamus plays a crucial role in modulating the cortical activity underlying sensory and cognitive processes. In particular, recent experimental findings highlighted that the thalamus does not merely act as a binary gate for sensory stimuli, but rather participates to the processing of sensory information. Clarifying such thalamic influence on cortical dynamics is also important as the thalamus is the target of therapies such as DBS for Tourette patients.

A Modified Novel Technique for Condylar Positioning in Mandibular Bilateral Sagittal Split Osteotomy Using Computer-Assisted Designed and Computer-Assisted Manufactured Surgical Guides.

Current techniques for orthognathic surgery after Le Fort I osteotomy and bilateral sagittal split osteotomy (BSSO) rely on intermediate and final occlusal splints for proper positioning of the dental arches without any control in positioning the condyle and ramus segments. Setting the 2 condyles in centric relation in the glenoid fossae at fixation is paramount for condylar function and the accuracy and stability of postoperative occlusion. Usually the 2 ramus segments are manually positioned and fixated in the final position according to the surgeon's experience.

Novel design for a customized, 3D-printed surgical template for thoracic spinal arthrodesis.

Background: The integration of computer-aided design/computer-aided manufacturing (CAD/CAM) tools and medicine is rapidly developing for designing medical devices. A novel design for a 3D-printed patient-specific surgical template for thoracic pedicle screw insertion, using a procedure based on reverse engineering, is presented.

Methods: The surgeon chooses the entry point on the vertebra.